Reinforcing one-carbon metabolism via folic acid/Folr1 promotes β-cell differentiation
Christos Karampelias, Habib Rezanejad, Mandy Rosko and 8 more
Nature Communications · 2021
doi:10.1038/s41467-021-23673-0 (opens in a new tab)
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Abstract
Regeneration of insulin-producing beta-cells may become a future alternative treatment of diabetes. Here the authors report a genetic screen in a zebrafish model that mimics the loss of beta-cells in diabetes, and identified that the folate receptor Folr1 or folinic acid treatment can stimulate beta-cell regeneration.
Abstract licence: CC BY-NC-ND
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