The lysosomal Ragulator complex plays an essential role in leukocyte trafficking by activating myosin II
Takeshi Nakatani, Kohei Tsujimoto, JeongHoon Park and 12 more
Nature Communications · 2021
doi:10.1038/s41467-021-23654-3 (opens in a new tab)
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Abstract
Myosin II–mediated contractility is required for leukocyte migration. Here, authors show that lysosomes are involved in leukocyte migration by providing the platform where Ragulator complex interacts with the myosin phosphatase Rho-interacting protein (MPRIP) independently of mTORC1 and interferes with the interaction between MPRIP and a subunit of myosin light chain phosphatase (MLCP).
Abstract licence: CC BY-NC-ND
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