Structure and mechanism of the human NHE1-CHP1 complex
Yanli Dong, Yiwei Gao, Alina Ilie and 6 more
Nature Communications · 2021
doi:10.1038/s41467-021-23496-z (opens in a new tab)
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Abstract
Sodium/proton exchanger 1 (NHE1) and its obligate binding partner Calcineurin B-homologous protein 1 (CHP1) regulate intracellular pH and volume homeostasis. Structures of the human NHE1-CHP1 complex offer insight into the regulation of NHE1 pH-sensitivity by CHP1 and into the interactions with NHE1 inhibitors.
Abstract licence: CC BY-NC-ND
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