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Structure and mechanism of the human NHE1-CHP1 complex

Yanli Dong, Yiwei Gao, Alina Ilie and 6 more

Nature Communications · 2021

doi:10.1038/s41467-021-23496-z (opens in a new tab)

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Abstract

Sodium/proton exchanger 1 (NHE1) and its obligate binding partner Calcineurin B-homologous protein 1 (CHP1) regulate intracellular pH and volume homeostasis. Structures of the human NHE1-CHP1 complex offer insight into the regulation of NHE1 pH-sensitivity by CHP1 and into the interactions with NHE1 inhibitors.

Abstract licence: CC BY-NC-ND

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