Structural basis of norepinephrine recognition and transport inhibition in neurotransmitter transporters
Shabareesh Pidathala, Aditya Kumar Mallela, Deepthi Joseph and 1 more
Nature Communications · 2021
doi:10.1038/s41467-021-22385-9 (opens in a new tab)
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Abstract
The Drosophila dopamine transporter (dDAT) is a catecholamine neurotransmitter transporter that resembles the human norepinephrine transporter (hNET). Here the authors report X-ray structures of the dDAT in substrate-free form, norepinephrine-bound form and dDAT bound to commonly prescribed chronic pain inhibitors duloxetine, milnacipran and tramadol and shed light on the structural basis of norepinephrine recognition and transport inhibition in neurotransmitter transporters.
Abstract licence: CC BY-NC-ND
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