The amyloid structure of mouse RIPK3 (receptor interacting protein kinase 3) in cell necroptosis
Xia-lian Wu, Hong Hu, Xing-qi Dong and 9 more
Nature Communications · 2021
doi:10.1038/s41467-021-21881-2 (opens in a new tab)
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Abstract
Receptor Interacting Protein Kinase 3 (RIPK3) has a key role in TNF-induced necroptosis. Here, the authors combine solid state NMR measurements, MD simulations and cell based assays to characterize mouse RIPK3 and they present the structure of the RIPK3 amyloid core.
Abstract licence: CC BY-NC-ND
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