N4BP1 negatively regulates NF-κB by binding and inhibiting NEMO oligomerization

NF-κB signalling is critical to TLR mediated cytokine release in various immune responses. Here the authors show how N4BP1 inhibits NEMO signalling and subsequent NF-κB activation and how this pathway is negatively regulated by caspase-8 cleavage of N4BP1.

Abstract licence: CC BY-NC-ND

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