Optical tweezers-controlled hotspot for sensitive and reproducible surface-enhanced Raman spectroscopy characterization of native protein structures
Xin Dai, Wenhao Fu, Huanyu Chi and 5 more
Nature Communications · 2021
doi:10.1038/s41467-021-21543-3 (opens in a new tab)
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Abstract
It is currently challenging to identify protein structures at low concentrations. Here the authors report optical tweezers-coupled Raman spectroscopy to generate tunable and reproducible SERS enhancements with single-molecule level sensitivity and use the method to detect protein structural features.
Abstract licence: CC BY-NC-ND
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