Three-component radical homo Mannich reaction
Shuai Shi, Wenting Qiu, Pannan Miao and 3 more
Nature Communications · 2021
doi:10.1038/s41467-021-21303-3 (opens in a new tab)
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Abstract
Due to the ionic nature of its mechanism, the Mannich reaction can only use non-enolizable aldehydes as substrates. Here, the authors expand the scope of the classical Mannich reaction to enolizable aldehydes by employing a radical process resulting in a streamlined synthesis of γ-amino-carbonyl compounds.
Abstract licence: CC BY-NC-ND
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