SARS-CoV-2 induces robust germinal center CD4 T follicular helper cell responses in rhesus macaques
Yashavanth Shaan Lakshmanappa, Sonny R. Elizaldi, Jamin W. Roh and 30 more
Nature Communications · 2021
doi:10.1038/s41467-020-20642-x (opens in a new tab)
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Abstract
Induction of CD4 T follicular helper (Tfh) cells is important for antibody responses to viral infections. Here, the authors show in a rhesus macaque model of mild COVID-19 that SARS-CoV-2 infection results in transient accumulation of proliferating Tfh cells with a Th1 profile in peripheral blood and generation of germinal center Tfh cells specific for viral proteins.
Abstract licence: CC BY-NC-ND
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