ZBP1 promotes LPS-induced cell death and IL-1β release via RHIM-mediated interactions with RIPK1
Hayley I. Muendlein, Wilson M. Connolly, Zoie Magri and 5 more
Nature Communications · 2021
doi:10.1038/s41467-020-20357-z (opens in a new tab)
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Abstract
Yersiania YopJ protein has been shown to drive caspase-8-mediated pyroptosis. Here the authors show a precise mechanism of this non-canonical cell death pathway that is controlled by a TRIF-dependent complex of FADD, RIPK1, caspase-8 and ZBP1.
Abstract licence: CC BY-NC-ND
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