Direct reprogramming of human umbilical vein- and peripheral blood-derived endothelial cells into hepatic progenitor cells
Hiroki Inada, Miyako Udono, Kanae Matsuda-Ito and 14 more
Nature Communications · 2020
doi:10.1038/s41467-020-19041-z (opens in a new tab)
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Abstract
The conditions to induce human hepatic progenitor cells from other cell types are unclear. Here, the authors reprogram human endothelial cells to hepatic progenitor cells by expressing FOXA3, HNF1A and HNF6, capable of giving rise to hepatocytes and cholangiocytes that reconstitute damaged liver tissues on transplantation.
Abstract licence: CC BY-NC-ND
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