Single-cell RNA cap and tail sequencing (scRCAT-seq) reveals subtype-specific isoforms differing in transcript demarcation
Youjin Hu, Jiawei Zhong, Yuhua Xiao and 9 more
Nature Communications · 2020
doi:10.1038/s41467-020-18976-7 (opens in a new tab)
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Abstract
Most single-cell RNA sequencing methods have limited ability to profile the transcriptome at isoform resolution. Here the authors develop scRCAT-seq to characterize the 5′- and 3′-ends of transcripts in single cells, and identify cell-type specific alternative transcript isoforms.
Abstract licence: CC BY-NC-ND
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