Pan-cancer analysis reveals TAp63-regulated oncogenic lncRNAs that promote cancer progression through AKT activation
Marco Napoli, Xiaobo Li, Hayley D. Ackerman and 14 more
Nature Communications · 2020
doi:10.1038/s41467-020-18973-w (opens in a new tab)
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Abstract
Mutations in TP53 and hyperactivation of the PI3K/AKT pathway are the two most frequent drivers of cancer progression across multiple human tumour types. Here, the authors identify two TAp63 regulated long non-coding RNAs, TROLL-2 and TROLL-3, that connect these oncogenic pathways, thus promoting tumour and metastasis formation in a wide variety of cancer types.
Abstract licence: CC BY-NC-ND
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