Adaptive thermogenesis enhances the life-threatening response to heat in mice with an Ryr1 mutation
Hui J. Wang, Chang Seok Lee, Rachel Sue Zhen Yee and 20 more
Nature Communications · 2020
doi:10.1038/s41467-020-18865-z (opens in a new tab)
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Abstract
Individuals with malignant hyperthermia susceptibility (MHS) suffer from lifethreatening responses to heat. Here the authors demonstrate that adaptive thermogenesis from brown adipose tissue contributes to this heat sensitivity in a preclinical mouse model of MHS
Abstract licence: CC BY-NC-ND
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