An FGF15/19-TFEB regulatory loop controls hepatic cholesterol and bile acid homeostasis
Yifeng Wang, Sumedha Gunewardena, Feng Li and 9 more
Nature Communications · 2020
doi:10.1038/s41467-020-17363-6 (opens in a new tab)
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Abstract
TFEB is a transcriptional regulator of lysosomal biogenesis, activated upon starvation or lysosomal stress. Here the authors report that TFEB regulates hepatic bile acid synthesis downstream of FGF19 signaling.
Abstract licence: CC BY-NC-ND
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