mTOR and S6K1 drive polycystic kidney by the control of Afadin-dependent oriented cell division
Martina Bonucci, Nicolas Kuperwasser, Serena Barbe and 15 more
Nature Communications · 2020
doi:10.1038/s41467-020-16978-z (opens in a new tab)
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Abstract
mTOR activation is known to generate polycystic kidneys, which show both increased proliferation and loss of oriented cell division (OCD). Here, Bonucci et al. show that loss of OCD is linked to S6K1 activation through its direct target Afadin and is separable from hyperproliferation.
Abstract licence: CC BY-NC-ND
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