A nanobody-based fluorescent reporter reveals human α-synuclein in the cell cytosol
Christoph Gerdes, Natalia Waal, Thomas Offner and 12 more
Nature Communications · 2020
doi:10.1038/s41467-020-16575-0 (opens in a new tab)
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Abstract
α-Syn in CSF is a biomarker of neurodegenerative diseases; however, the detection of clinically relevant species is difficult. Here, the authors create a nanobody biosensor that reveals the presence of α-Syn in cells, which allow the detection of transmittable forms of α-Syn present in human CSF.
Abstract licence: CC BY-NC-ND
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