A genome-wide gain-of-function screen identifies CDKN2C as a HBV host factor
Carla Eller, Laura Heydmann, Che C. Colpitts and 20 more
Nature Communications · 2020
doi:10.1038/s41467-020-16517-w (opens in a new tab)
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Abstract
Here the authors perform a gain-of-function screen and identify CDKN2C as a host factor for HBV replication, inducing cell cycle arrest and expression of HBV transcription enhancers. CDKN2C expression correlates with disease progression suggesting a potential role in HBV-induced liver disease.
Abstract licence: CC BY-NC-ND
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