Kinesin-14 motors drive a right-handed helical motion of antiparallel microtubules around each other
Aniruddha Mitra, Laura Meißner, Rojapriyadharshini Gandhimathi and 3 more
Nature Communications · 2020
doi:10.1038/s41467-020-16328-z (opens in a new tab)
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Abstract
Some kinesins exhibit off-axis power strokes but their impact on motility and force generation in microtubule overlaps has not been investigated so far. Here authors use a 3D in vitro motility assay and find that Ndc’s off-axis motor forces generate torque in antiparallel microtubules which causes microtubule twisting and coiling.
Abstract licence: CC BY-NC-ND
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