Evolutionary conserved NSL complex/BRD4 axis controls transcription activation via histone acetylation
Aline Gaub, Bilal N. Sheikh, M. Felicia Basilicata and 8 more
Nature Communications · 2020
doi:10.1038/s41467-020-16103-0 (opens in a new tab)
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Abstract
The MOF acetyltransferase-containing Non-Specific Lethal (NSL) complex is a broad transcription regulator and haploinsufficiency of its KANSL1 subunit results in the Koolen-de Vries syndrome in humans. Here, the authors identify the BET protein BRD4 as evolutionary conserved co-factor of the NSL complex and provide evidence that NSL-deposited histone acetylation induces BRD4 recruitment for transcription of constitutively active genes.
Abstract licence: CC BY-NC-ND
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