Deep brain stimulation-guided optogenetic rescue of parkinsonian symptoms
Sébastien Valverde, Marie Vandecasteele, Charlotte Piette and 6 more
Nature Communications · 2020
doi:10.1038/s41467-020-16046-6 (opens in a new tab)
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Abstract
Deep brain stimulation (DBS) is a symptomatic treatment of Parkinson’s disease (PD) that benefits only a minority of patients. Here, the authors show that activation of cortical somatostatin interneurons alleviates motor symptoms in a mouse model of PD and may constitute a less invasive alternative than DBS.
Abstract licence: CC BY-NC-ND
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