Activity-dependent isomerization of Kv4.2 by Pin1 regulates cognitive flexibility
Jia–Hua Hu, Cole Malloy, G. Travis Tabor and 7 more
Nature Communications · 2020
doi:10.1038/s41467-020-15390-x (opens in a new tab)
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Abstract
K + channels function in macromolecular complexes with accessory subunits to regulate neuronal function. Here, the authors describe Pin1-mediated regulation of the Kv4.2 complex, which impacts reversal learning in mice, providing potential treatment for disorders characterized by cognitive inflexibility.
Abstract licence: CC BY-NC-ND
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