The epichaperome is a mediator of toxic hippocampal stress and leads to protein connectivity-based dysfunction
Maria Carmen Inda, Suhasini Joshi, Tai Wang and 36 more
Nature Communications · 2020
doi:10.1038/s41467-019-14082-5 (opens in a new tab)
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Abstract
The biology of Alzheimer’s disease (AD) remains unknown. We propose AD is a protein connectivity-based dysfunction disorder whereby a switch of the chaperome into epichaperomes rewires proteome-wide connectivity, leading to brain circuitry malfunction that can be corrected by novel therapeutics.
Abstract licence: CC BY-NC-ND
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