Structural basis for adhesion G protein-coupled receptor Gpr126 function
Katherine Leon, Rebecca L. Cunningham, Joshua A. Riback and 6 more
Nature Communications · 2020
doi:10.1038/s41467-019-14040-1 (opens in a new tab)
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Abstract
The extracellular regions (ECRs) of adhesion GPCRs have diverse biological functions, but their structures and mechanisms of action remain unclear. Here, the authors solve the ECR structure of the Gpr126 receptor and show that ECR conformation and signaling functions are regulated by alternative splicing.
Abstract licence: CC BY-NC-ND
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