Discovery of a chemical probe for PRDM9
Abdellah Allali-Hassani, Magdalena M. Szewczyk, Danton Ivanochko and 27 more
Nature Communications · 2019
doi:10.1038/s41467-019-13652-x (opens in a new tab)
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Abstract
PRDM9 is a PR domain containing histone methyl transferase which expression is normally restricted to the germline that has also been linked to a number of somatic cancers. Here the authors describe the identification of a small molecule that selectivity inhibits the methyltransferase activity of PRDM9 in biochemical and cellular assays
Abstract licence: CC BY-NC-ND
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