Challenging immunodominance of influenza-specific CD8+ T cell responses restricted by the risk-associated HLA-A*68:01 allomorph
C. E. van de Sandt, E. B. Clemens, E. J. Grant and 14 more
Nature Communications · 2019
doi:10.1038/s41467-019-13346-4 (opens in a new tab)
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Abstract
The HLA-A*68:01 allele has been associated with severe influenza disease during the 2009 influenza pandemic. Here, the authors analyze influenza nucleoprotein specific HLA-A*68:01-restricted CD8+ T cells from human donors and show immunodominance of these cells in approximately 35% of HLA-A*68:01-expressing donors.
Abstract licence: CC BY-NC-ND
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