Targeting specificity of APOBEC-based cytosine base editor in human iPSCs determined by whole genome sequencing
Erica McGrath, Hyunsu Shin, Linyi Zhang and 6 more
Nature Communications · 2019
doi:10.1038/s41467-019-13342-8 (opens in a new tab)
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Abstract
Cytidine base editors are powerful tools for making subtle genome alterations. Here the authors analyse edited human iPSCs with whole genome sequencing and reveal the spectrum of off-target effects.
Abstract licence: CC BY-NC-ND
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