The structure of a polygamous repressor reveals how phage-inducible chromosomal islands spread in nature
J. Rafael Ciges-Tomas, Christian Alite, Suzanne Humphrey and 5 more
Nature Communications · 2019
doi:10.1038/s41467-019-11504-2 (opens in a new tab)
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Abstract
Staphylococcus aureus pathogenicity islands (SaPIs) encode the master repressor Stl and after bacteriophage infection Stl interacts with specific phage proteins leading to a derepression of SaPIs. Here the authors provide structural insights into this family of repressors by determining the crystal structures of SaPIbov1 Stl alone and in complex with two structurally unrelated phage dUTPases.
Abstract licence: CC BY-NC-ND
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