The Eleanor ncRNAs activate the topological domain of the ESR1 locus to balance against apoptosis
Mohamed Osama Ali Abdalla, Tatsuro Yamamoto, Kazumitsu Maehara and 8 more
Nature Communications · 2019
doi:10.1038/s41467-019-11378-4 (opens in a new tab)
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Abstract
Long term estrogen deprivation can result in apoptosis in breast cancer cells. Here, the authors show that this apoptosis is induced by the long-range chromatin interaction of loci containing the ESR1 and FOXO 3 genes, resulting in FOXO 3-mediated apoptosis.
Abstract licence: CC BY-NC-ND
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