ER-residential Nogo-B accelerates NAFLD-associated HCC mediated by metabolic reprogramming of oxLDL lipophagy
Yuan Tian, Bin Yang, Weinan Qiu and 18 more
Nature Communications · 2019
doi:10.1038/s41467-019-11274-x (opens in a new tab)
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Abstract
Non alcoholic fatty liver disease (NAFLD) associates with an elevated risk of developing hepatocellular carcinoma (HCC). Here, the authors find that Nogo-B, an endoplasmic reticulum resident protein, is upregulated by lipid uptake and acts as an oncogene in NAFLD-associated HCC by promoting lipid droplet breakdown by lipophagy and triggering Hippo pathway dysregulation
Abstract licence: CC BY-NC-ND
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