Spinal neural tube closure depends on regulation of surface ectoderm identity and biomechanics by Grhl2
Evanthia Nikolopoulou, Caroline S. Hirst, Gabriel Galea and 7 more
Nature Communications · 2019
doi:10.1038/s41467-019-10164-6 (opens in a new tab)
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Abstract
Loss or over-expression of Grainyhead-like transcription factors (Grhl) prevents closure of the neural tube but the mechanism underlying this is unclear. Here, the authors show that Grhl2 regulates murine posterior-neuropore closure via changes in the identity and biomechanics of the non-neural, surface ectoderm cells.
Abstract licence: CC BY-NC-ND
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