Dynamic gene regulation by nuclear colony-stimulating factor 1 receptor in human monocytes and macrophages
Laura Bencheikh, M’Boyba Khadija Diop, Julie Rivière and 10 more
Nature Communications · 2019
doi:10.1038/s41467-019-09970-9 (opens in a new tab)
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Abstract
Receptor tyrosine kinases localize to the cell surface and have been suggested to also have nuclear function. Here the authors provide evidence that Colony Stimulating Factor-1 Receptor (CSF-1R) migrates to the nucleus upon CSF-1 stimulation in monocytes and that upon differentiation into macrophages, CSF-1R localizes to TSS, co-localizes with H3K4me3, and interacts with ELK and YY1.
Abstract licence: CC BY-NC-ND
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