A MST1–FOXO1 cascade establishes endothelial tip cell polarity and facilitates sprouting angiogenesis
Yoo Hyung Kim, Jeongwoon Choi, Myung Jin Yang and 5 more
Nature Communications · 2019
doi:10.1038/s41467-019-08773-2 (opens in a new tab)
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Abstract
Angiogenesis is driven by the directed migration of tip endothelial cells towards hypoxic tissues. Here, Kim et al. show that the generation of reactive oxygen species in endothelial cells upon hypoxia activates MST1, which subsequently promotes the nuclear translocation of FOXO1, and thus activates a pro-migratory transcriptional programme in endothelial tip cells.
Abstract licence: CC BY-NC-ND
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