Evolution of a General RNA-Cleaving FANA Enzyme
Yajun Wang, Arlene K. Ngor, Ali Nikoomanzar and 1 more
Nature Communications · 2018
doi:10.1038/s41467-018-07611-1 (opens in a new tab)
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Abstract
Artificial genetic polymers (XNAs) have been explored for their nuclease activity, but XNAzymes have proven challenging to discover by in vitro selection. Here, the authors generate an efficient RNA-cleaving 2’-fluoroarabino nucleic acid enzyme (FANAzyme) by in vitro evolution using natural DNA polymerases.
Abstract licence: CC BY-NC-ND
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