Cardiac specific PRMT1 ablation causes heart failure through CaMKII dysregulation
Jung-Hoon Pyun, Hyun-Ji Kim, Myong-Ho Jeong and 7 more
Nature Communications · 2018
doi:10.1038/s41467-018-07606-y (opens in a new tab)
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Abstract
The mechanisms that regulate the activity of Ca2 +/calmodulin-dependent protein kinase II (CaMKII) in the context of heart failure are incompletely understood. Here the authors show that protein arginine methyltransferase 1 (PRMT1) prevents cardiac hyperactivation of CaMKII and heart failure development by methylating CaMKII at arginine residues 9 and 275.
Abstract licence: CC BY-NC-ND
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