Design and 22-step synthesis of highly potent D-ring modified and linker-equipped analogs of spongistatin 1
Linda M. Suen, Makeda A. Tekle-Smith, Kevin S. Williamson and 6 more
Nature Communications · 2018
doi:10.1038/s41467-018-07259-x (opens in a new tab)
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Abstract
Step-economical and efficient syntheses of Spongistatin 1 analogs are desirable for the development of potent anti-proliferative agents. Here, the authors report a 22-step synthesis of a D-ring modified Spongistatin 1 analog with retained picomolar potency among a group of C(15) ester derivatives.
Abstract licence: CC BY-NC-ND
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