Rational design of a triple-type human papillomavirus vaccine by compromising viral-type specificity
Zhihai Li, Shuo Song, Maozhou He and 18 more
Nature Communications · 2018
doi:10.1038/s41467-018-07199-6 (opens in a new tab)
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Abstract
More than 18 human papillomaviruses (HPV) are associated with cervical cancer, and ideally vaccines should protect from all of them. Here, the authors engineer a triple-type, chimeric HPV vaccine, using loop swapping, that elicits robust neutralizing antibody titers in mice and non-human primates.
Abstract licence: CC BY-NC-ND
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