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Iridium-catalyzed reductive Ugi-type reactions of tertiary amides

Lan-Gui Xie, Darren J. Dixon

Nature Communications · 2018

doi:10.1038/s41467-018-05192-7 (opens in a new tab)

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Abstract

Chemical transformation of amides is normally occurring under harsh conditions. Here, the authors report a mild iridium-catalyzed reductive Ugi-type coupling of tertiary amides, isocyanides and (thio)acetic acid or trimethylsilyl azide to give homologous, bioactive amine products.

Abstract licence: CC BY-NC-ND

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