MLL-fusion-driven leukemia requires SETD2 to safeguard genomic integrity
Anna Skucha, Jessica Ebner, Johannes Schmöllerl and 17 more
Nature Communications · 2018
doi:10.1038/s41467-018-04329-y (opens in a new tab)
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Abstract
In leukemia, diverse fusion proteins involving the MLL gene can drive oncogenic activity. Here, the authors describe a dependency of MLL-leukemia cells on the methyltransferase SETD2 to maintain genomic integrity during leukemia initiation and maintenance.
Abstract licence: CC BY-NC-ND
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