Direct binding of CEP85 to STIL ensures robust PLK4 activation and efficient centriole assembly
Yi Liu, Gagan D. Gupta, Deepak D. Barnabas and 13 more
Nature Communications · 2018
doi:10.1038/s41467-018-04122-x (opens in a new tab)
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Abstract
Centriole duplication is tightly regulated in vivo, but the underlying molecular mechanisms are incompletely understood. Here the authors use high-resolution structural and imaging methods to show that CEP85 directly interacts with STIL and mediates efficient centriolar targeting of STIL, PLK4 activation and centriole assembly.
Abstract licence: CC BY-NC-ND
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