p38-MK2 signaling axis regulates RNA metabolism after UV-light-induced DNA damage
Marina E. Borisova, Andrea Voigt, Maxim A. X. Tollenaere and 9 more
Nature Communications · 2018
doi:10.1038/s41467-018-03417-3 (opens in a new tab)
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Abstract
UV-light-induced DNA damage affects RNA metabolism but the underlying signalling pathways are largely unexplored. Here, the authors show that UV light triggers p38-MK2-mediated phosphorylation of the NELF complex, promoting its release from chromatin and concurrent transcriptional elongation.
Abstract licence: CC BY-NC-ND
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