Partially native intermediates mediate misfolding of SOD1 in single-molecule folding trajectories
Supratik Sen Mojumdar, Zackary N. Scholl, Derek R. Dee and 4 more
Nature Communications · 2017
doi:10.1038/s41467-017-01996-1 (opens in a new tab)
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Abstract
Misfolding of superoxide dismutase 1 (SOD1) is linked to amyotrophic lateral sclerosis. Here the authors characterize the unfolding/refolding of single SOD1 molecules using optical tweezers, identifying partially folded intermediates that lead to misfolding after the formation of a native-like core.
Abstract licence: CC BY-NC-ND
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