Molecular architecture of the PBP2–MreC core bacterial cell wall synthesis complex

Bacterial wall biosynthesis is a complex process that requires the coordination of multiple enzymes. Here, the authors structurally characterize the PBP2:MreC complex involved in peptidoglycan elongation and cross-linking, and demonstrate that its disruption leads to loss of H. pylori shape and inability to sustain growth.

Abstract licence: CC BY-NC-ND

• A central role for PBP2 in the activation of peptidoglycan polymerization by the bacterial cell elongation machinery · 2018

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