Protein O-fucosylation in Plasmodium falciparum ensures efficient infection of mosquito and vertebrate hosts
Sash Lopaticki, Annie S. P. Yang, Alan John and 11 more
Nature Communications · 2017
doi:10.1038/s41467-017-00571-y (opens in a new tab)
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Abstract
The role of O-glycosylation in the malaria life cycle is largely unknown. Here, the authors identify a Plasmodium protein O-fucosyltransferase and show that it is important for normal trafficking of a subset of surface proteins, particularly CSP and TRAP, and efficient infection of mosquito and vertebrate hosts.
Abstract licence: CC BY-NC-ND
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