CDYL suppresses epileptogenesis in mice through repression of axonal Nav1.6 sodium channel expression
Yongqing Liu, Shirong Lai, Weining Ma and 11 more
Nature Communications · 2017
doi:10.1038/s41467-017-00368-z (opens in a new tab)
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Abstract
Alterations in intrinsic plasticity are important in epilepsy. Here the authors show that the epigenetic factor CDYL regulates the gene expression of the voltage gated sodium channel, Nav1.6, which contributes to seizures in a rat model of epilepsy.
Abstract licence: CC BY-NC-ND
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