Insight into microtubule disassembly by kinesin-13s from the structure of Kif2C bound to tubulin
Weiyi Wang, Soraya Cantos-Fernandes, Yuncong Lv and 4 more
Nature Communications · 2017
doi:10.1038/s41467-017-00091-9 (opens in a new tab)
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Abstract
Kinesin-13s are microtubule depolymerizing enzymes. Here the authors present the crystal structure of a DARPin fused construct comprising the short neck region and motor domain of kinesin-13 in complex with an αβ-tubulin heterodimer, which shows that kinesin-13 functions by stabilizing a curved tubulin conformation.
Abstract licence: CC BY-NC-ND
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