No retraction, correction or concern found when last checked on Oct 23, 2026.

RNA modifications in cellular metabolism: implications for metabolism-targeted therapy and immunotherapy

Wei-Wei Liu, Si-Qing Zheng, Tian Li and 6 more

Signal Transduction and Targeted Therapy · 2024 · Review · CC BY

Abstract

Cellular metabolism is an intricate network satisfying bioenergetic and biosynthesis requirements of cells. Relevant studies have been constantly making inroads in our understanding of pathophysiology, and inspiring development of therapeutics. As a crucial component of epigenetics at post-transcription level, RNA modification significantly determines RNA fates, further affecting various biological processes and cellular phenotypes. To be noted, immunometabolism defines the metabolic alterations occur on immune cells in different stages and immunological contexts. In this review, we characterize the distribution features, modifying mechanisms and biological functions of 8 RNA modifications, including N6-methyladenosine (m6A), N6,2′-O-dimethyladenosine (m6Am), N1-methyladenosine (m1A), 5-methylcytosine (m5C), N4-acetylcytosine (ac4C), N7-methylguanosine (m7G), Pseudouridine (Ψ), adenosine-to-inosine (A-to-I) editing, which are relatively the most studied types. Then regulatory roles of these RNA modification on metabolism in diverse health and disease contexts are comprehensively described, categorized as glucose, lipid, amino acid, and mitochondrial metabolism. And we highlight the regulation of RNA modifications on immunometabolism, further influencing immune responses. Above all, we provide a thorough discussion about clinical implications of RNA modification in metabolism-targeted therapy and immunotherapy, progression of RNA modification-targeted agents, and its potential in RNA-targeted therapeutics. Eventually, we give legitimate perspectives for future researches in this field from methodological requirements, mechanistic insights, to therapeutic applications.

References 460

1.
MODOMICS: a database of RNA modification pathways. 2021 update · 2021
No notice
2.
Yue Y, Liu J, He C. RNA N6-methyladenosine methylation in post-transcriptional gene expression regulation. Genes Dev. 2015;29:1343-1355.
Not in our library10.1101/gad.262766.115
3.
Metabolic landscape of the tumor microenvironment at single cell resolution · 2019
No notice
4.
Koenen M, Hill MA, Cohen P, Sowers JR. Obesity, adipose tissue and vascular dysfunction. Circ. Res. 2021;128:951-968.
Not in our library10.1161/circresaha.121.318093
5.
Boulton A. Strengthening the International Diabetes Federation (IDF). Diabetes Res Clin. Pract. 2020;160:108029.
Not in our library10.1016/j.diabres.2020.108029
6.
Powell EE, Wong VW, Rinella M. Non-alcoholic fatty liver disease. Lancet. 2021;397:2212-2224.
Not in our library10.1016/s0140-6736(20)32511-3
7.
Long GV, et al. Epacadostat plus pembrolizumab versus placebo plus pembrolizumab in patients with unresectable or metastatic melanoma (ECHO-301/KEYNOTE-252): a phase 3, randomised, double-blind study. Lancet Oncol. 2019;20:1083-1097.
Not in our library10.1016/s1470-2045(19)30274-8
8.
Tannir NM, et al. Efficacy and safety of telaglenastat plus cabozantinib vs placebo plus cabozantinib in patients with advanced renal cell carcinoma: the CANTATA randomized clinical trial. JAMA Oncol. 2022;8:1411-1418.
Not in our library10.1001/jamaoncol.2022.3511
9.
Goodwin PJ, et al. Effect of metformin vs placebo on invasive disease-free survival in patients with breast cancer: the MA.32 randomized clinical trial. JAMA. 2022;327:1963-1973.
Not in our library10.1001/jama.2022.6147
10.
The role of m6A RNA methylation in cancer metabolism · 2022
No notice
11.
Cai X, et al. N6-methyladenosine modification and metabolic reprogramming of digestive system malignancies. Cancer Lett. 2022;544:215815.
Not in our library10.1016/j.canlet.2022.215815
12.
m6A-regulated tumor glycolysis: new advances in epigenetics and metabolism · 2023
No notice
13.
Everts B, et al. Commitment to glycolysis sustains survival of NO-producing inflammatory dendritic cells. Blood. 2012;120:1422-1431.
Not in our library10.1182/blood-2012-03-419747
14.
Akkaya M, et al. Second signals rescue B cells from activation-induced mitochondrial dysfunction and death. Nat. Immunol. 2018;19:871.
Not in our library10.1038/s41590-018-0156-5
15.
Lauterbach MA, et al. Toll-like receptor signaling rewires macrophage metabolism and promotes histone acetylation via ATP-citrate lyase. Immunity. 2019;51:997.
Not in our library10.1016/j.immuni.2019.11.009
16.
Wang RN, et al. The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation. Immunity. 2011;35:871-882.
Not in our library10.1016/j.immuni.2011.09.021
17.
Cohn WE, Volkin E. Nucleoside-5′-phosphates from ribonucleic acid. Nature. 1951;167:483-484.
Not in our library10.1038/167483a0
18.
Holley RW, Everett GA, Madison JT, Zamir A. Nucleotide sequences in the yeast alanine transfer ribonucleic acid. J. Biol. Chem. 1965;240:2122-2128.
Not in our library10.1016/s0021-9258(18)97435-1
19.
Jia GF, et al. N6-Methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO. Nat. Chem. Biol. 2011;7:885-887.
Not in our library10.1038/nchembio.687
20.
Desrosiers R, Friderici K, Rottman F. Identification of methylated nucleosides in messenger RNA from Novikoff hepatoma cells. Proc. Natl Acad. Sci. USA. 1974;71:3971-3975.
Not in our library10.1073/pnas.71.10.3971
21.
Adams JM, Cory S. Modified nucleosides and bizarre 5′-termini in mouse myeloma mRNA. Nature. 1975;255:28-33.
Not in our library10.1038/255028a0
22.
Modifications and functional genomics of human transfer RNA · 2018
No notice
23.
Lyons SM, Fay MM, Ivanov P. The role of RNA modifications in the regulation of tRNA cleavage. FEBS Lett. 2018;592:2828-2844.
Not in our library10.1002/1873-3468.13205
24.
Jacob R, Zander S, Gutschner T. The dark side of the epitranscriptome: chemical modifications in long non-coding RNAs. Int J. Mol. Sci. 2017;18:2387.
Not in our library10.3390/ijms18112387
25.
Aberrant NSUN2-mediated m5C modification of H19 lncRNA is associated with poor differentiation of hepatocellular carcinoma · 2020
No notice
26.
Meyer KD, et al. Comprehensive analysis of mRNA methylation reveals enrichment in 3′ UTRs and near stop codons. Cell. 2012;149:1635-1646.
Not in our library10.1016/j.cell.2012.05.003
27.
Huang H, Weng H, Chen J. m(6)A modification in coding and non-coding RNAs: roles and therapeutic implications in cancer. Cancer Cell. 2020;37:270-288.
Not in our library10.1016/j.ccell.2020.02.004
28.
Wang Y, et al. N6-methyladenosine modification destabilizes developmental regulators in embryonic stem cells. Nat. Cell Biol. 2014;16:191-198.
Not in our library10.1038/ncb2902
29.
Fustin JM, et al. RNA-methylation-dependent RNA processing controls the speed of the circadian clock. Cell. 2013;155:793-806.
Not in our library10.1016/j.cell.2013.10.026
30.
Aguilo F, et al. Coordination of m(6)A mRNA methylation and gene transcription by ZFP217 regulates pluripotency and reprogramming. Cell Stem Cell. 2015;17:689-704.
Not in our library10.1016/j.stem.2015.09.005
31.
Schwartz S, et al. High-resolution mapping reveals a conserved, widespread, dynamic mRNA methylation program in yeast meiosis. Cell. 2013;155:1409-1421.
Not in our library10.1016/j.cell.2013.10.047
32.
FTO is required for myogenesis by positively regulating mTOR-PGC-1α pathway-mediated mitochondria biogenesis · 2017
No notice
33.
Dina C, et al. Variation in FTO contributes to childhood obesity and severe adult obesity. Nat. Genet. 2007;39:724-726.
Not in our library10.1038/ng2048
34.
Liu J, et al. A METTL3-METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation. Nat. Chem. Biol. 2014;10:93-95.
Not in our library10.1038/nchembio.1432
35.
Wang P, Doxtader KA, Nam Y. Structural basis for cooperative function of Mettl3 and Mettl14 methyltransferases. Mol. Cell. 2016;63:306-317.
Not in our library10.1016/j.molcel.2016.05.041
36.
Solution structure of the RNA recognition domain of METTL3-METTL14 N6-methyladenosine methyltransferase · 2018
No notice
37.
Ping XL, et al. Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase. Cell Res. 2014;24:177-189.
Not in our library10.1038/cr.2014.3
38.
Patil DP, et al. m(6)A RNA methylation promotes XIST-mediated transcriptional repression. Nature. 2016;537:369-373.
Not in our library10.1038/nature19342
39.
Bokar JA, et al. Characterization and partial purification of mRNA N6-adenosine methyltransferase from HeLa cell nuclei. Internal mRNA methylation requires a multisubunit complex. J. Biol. Chem. 1994;269:17697-17704.
Not in our library10.1016/s0021-9258(17)32497-3
40.
Pendleton KE, et al. The U6 snRNA m(6)A methyltransferase METTL16 regulates SAM synthetase intron retention. Cell. 2017;169:824.
Not in our library10.1016/j.cell.2017.05.003
41.
Shima H, et al. S-adenosylmethionine synthesis is regulated by selective N-6-adenosine methylation and mRNA degradation involving METTL16 and YTHDC1. Cell Rep. 2017;21:3354-3363.
Not in our library10.1016/j.celrep.2017.11.092
42.
Ma HH, et al. N-6-Methyladenosine methyltransferase ZCCHC4 mediates ribosomal RNA methylation (vol 15, pg 88, 2019). Nat. Chem. Biol. 2019;15:549-549.
Not in our library10.1038/s41589-019-0233-6
43.
Ignatova VV, et al. The rRNA m(6)A methyltransferase METTL5 is involved in pluripotency and developmental programs. Gene Dev. 2020;34:715-729.
Not in our library10.1101/gad.333369.119
44.
Jia GF, et al. N6-Methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO (vol 7, pg 885, 2011). Nat. Chem. Biol. 2012;8:1008-1008.
Not in our library10.1038/nchembio1212-1008a
45.
Mauer J, et al. Reversible methylation of m(6)A(m) in the 5′ cap controls mRNA stability. Nature. 2017;541:371-375.
Not in our library10.1038/nature21022
46.
Mauer J, Jaffrey SR. FTO, m(6) Am, and the hypothesis of reversible epitranscriptomic mRNA modifications. FEBS Lett. 2018;592:2012-2022.
Not in our library10.1002/1873-3468.13092
47.
Mauer J, et al. Reversible methylation of m(6)A(m) in the 5′ cap controls mRNA stability. Nature. 2017;541:371.
Not in our library10.1038/nature21022
48.
Zhang X, et al. Structural insights into FTO’s catalytic mechanism for the demethylation of multiple RNA substrates. Proc. Natl Acad. Sci. USA. 2019;116:2919-2924.
Not in our library10.1073/pnas.1820574116
49.
Wei J, et al. Differential m(6)A, m(6)A(m), and m(1)A demethylation mediated by FTO in the cell nucleus and cytoplasm. Mol. Cell. 2018;71:973-985.e975.
Not in our library10.1016/j.molcel.2018.08.011
50.
Zheng GQ, et al. ALKBH5 Is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility. Mol. Cell. 2013;49:18-29.
Not in our library10.1016/j.molcel.2012.10.015
51.
YTH Domain: A Family of N 6 -Methyladenosine (m 6 A) Readers · 2018
No notice
52.
ketu mutant mice uncover an essential meiotic function for the ancient RNA helicase YTHDC2 · 2018
No notice
53.
Zaccara S, Jaffrey SR. A unified model for the function of YTHDF proteins in regulating m(6)A-modified mRNA. Cell. 2020;181:1582-1595.e1518.
Not in our library10.1016/j.cell.2020.05.012
54.
YTHDC1 mediates nuclear export of N6-methyladenosine methylated mRNAs · 2017
No notice
55.
m6A in mRNA coding regions promotes translation via the RNA helicase-containing YTHDC2 · 2019
No notice
56.
Shi HL, et al. YTHDF3 facilitates translation and decay of N-6-methyladenosine-modified RNA. Cell Res. 2017;27:315-328.
Not in our library10.1038/cr.2017.15
57.
Orouji E, et al. Oncogenic role of an epigenetic reader of m(6)A RNA modification: YTHDF1 in merkel cell carcinoma. Cancers. 2020;12:202.
Not in our library10.3390/cancers12010202
58.
Huang H, et al. Recognition of RNA N(6)-methyladenosine by IGF2BP proteins enhances mRNA stability and translation. Nat. Cell Biol. 2018;20:285-295.
Not in our library10.1038/s41556-018-0045-z
59.
Feng MD, et al. YBX1 is required for maintaining myeloid leukemia cell survival by regulating BCL2 stability in an m(6)A-dependent manner. Blood. 2021;138:71-85.
Not in our library10.1182/blood.2020009676
60.
Liu N, et al. N-6-methyladenosine-dependent RNA structural switches regulate RNA-protein interactions. Nature. 2015;518:560-564.
Not in our library10.1038/nature14234
61.
Alarcon CR, et al. HNRNPA2B1 is a mediator of m(6)A-dependent nuclear RNA processing events. Cell. 2015;162:1299-1308.
Not in our library10.1016/j.cell.2015.08.011
62.
Zhou KI, et al. Regulation of co-transcriptional Pre-mRNA splicing by m(6)A through the low-complexity protein hnRNPG. Mol. Cell. 2019;76:70-81.e79.
Not in our library10.1016/j.molcel.2019.07.005
63.
A novel m6A reader Prrc2a controls oligodendroglial specification and myelination · 2018
No notice
64.
The Tudor SND1 protein is an m6A RNA reader essential for replication of Kaposi’s sarcoma-associated herpesvirus · 2019
No notice
65.
Zaccara S, Ries RJ, Jaffrey SR. Reading, writing and erasing mRNA methylation. Nat. Rev. Mol. Cell Biol. 2019;20:608-624.
Not in our library10.1038/s41580-019-0168-5
66.
Yang L, et al. Proteinase-activated receptor 2 promotes cancer cell migration through RNA methylation-mediated repression of miR-125b. J. Biol. Chem. 2015;290:26627-26637.
Not in our library10.1074/jbc.m115.667717
67.
Liu N, et al. N(6)-methyladenosine-dependent RNA structural switches regulate RNA-protein interactions. Nature. 2015;518:560-564.
Not in our library10.1038/nature14234
68.
Zheng ZQ, et al. Long noncoding RNA FAM225A promotes nasopharyngeal carcinoma tumorigenesis and metastasis by acting as ceRNA to sponge miR-590-3p/miR-1275 and upregulate ITGB3. Cancer Res. 2019;79:4612-4626.
Not in our library10.1158/0008-5472.can-19-0799
69.
N6-methyladenosine modification of circNSUN2 facilitates cytoplasmic export and stabilizes HMGA2 to promote colorectal liver metastasis · 2019
No notice
70.
Extensive translation of circular RNAs driven by N6-methyladenosine · 2017
No notice
71.
Paramasivam A, Vijayashree Priyadharsini J. Novel insights into m6A modification in circular RNA and implications for immunity. Cell Mol. Immunol. 2020;17:668-669.
Not in our library10.1038/s41423-020-0387-x
72.
Charenton C, Wilkinson ME, Nagai K. Mechanism of 5′ splice site transfer for human spliceosome activation. Science. 2019;364:362-367.
Not in our library10.1126/science.aax3289
73.
Wei C, Gershowitz A, Moss B. N6, O2′-dimethyladenosine a novel methylated ribonucleoside next to the 5′ terminal of animal cell and virus mRNAs. Nature. 1975;257:251-253.
Not in our library10.1038/257251a0
74.
Wang J, et al. Quantifying the RNA cap epitranscriptome reveals novel caps in cellular and viral RNA. Nucleic Acids Res. 2019;47:e130.
Not in our library10.1093/nar/gkz751
75.
Zhang Q, et al. HIV reprograms host m(6)Am RNA methylome by viral Vpr protein-mediated degradation of PCIF1. Nat. Commun. 2021;12:5543.
Not in our library10.1038/s41467-021-25683-4
76.
Wang L, et al. PCIF1-mediated deposition of 5′-cap N(6),2′-O-dimethyladenosine in ACE2 and TMPRSS2 mRNA regulates susceptibility to SARS-CoV-2 infection. Proc. Natl Acad. Sci. USA. 2023;120:e2210361120.
Not in our library10.1073/pnas.2210361120
77.
Sendinc E, et al. PCIF1 catalyzes m6Am mRNA methylation to regulate gene expression. Mol. Cell. 2019;75:620-630.e629.
Not in our library10.1016/j.molcel.2019.05.030
78.
Keith JM, Ensinger MJ, Moss B. HeLa cell RNA (2′-O-methyladenosine-N6-)-methyltransferase specific for the capped 5′-end of messenger RNA. J. Biol. Chem. 1978;253:5033-5039.
Not in our library10.1016/s0021-9258(17)34652-5
79.
Akichika S, et al. Cap-specific terminal N (6)-methylation of RNA by an RNA polymerase II-associated methyltransferase. Science. 2019;363:eaav0080.
Not in our library10.1126/science.aav0080
80.
Goh YT, et al. METTL4 catalyzes m6Am methylation in U2 snRNA to regulate pre-mRNA splicing. Nucleic Acids Res. 2020;48:9250-9261.
Not in our library10.1093/nar/gkaa684
81.
Structural insights into molecular mechanism for N 6-adenosine methylation by MT-A70 family methyltransferase METTL4 · 2022
Not checked
82.
Chen H, et al. METTL4 is an snRNA m(6)Am methyltransferase that regulates RNA splicing. Cell Res. 2020;30:544-547.
Not in our library10.1038/s41422-019-0270-4
83.
Goh YT, et al. METTL4 catalyzes m(6)Am methylation in U2 snRNA to regulate pre-mRNA splicing. Nucleic Acids Res. 2020;48:9250-9261.
Not in our library10.1093/nar/gkaa684
84.
Hao ZY, et al. N-6-deoxyadenosine methylation in mammalian mitochondrial DNA. Mol. Cell. 2020;78:382.
Not in our library10.1016/j.molcel.2020.02.018
85.
Zhang ZX, et al. Regulation of adipocyte differentiation by METTL4, a 6mA methylase. Sci Rep. 2020;10:1.
Not in our library10.1038/s41598-020-64873-w
86.
Hirayama M, et al. FTO demethylates cyclin D1 mRNA and controls cell-cycle progression. Cell Rep. 2020;31:107464.
Not in our library10.1016/j.celrep.2020.03.028
87.
Boulias K, et al. Identification of the m(6)Am methyltransferase PCIF1 reveals the location and functions of m(6)Am in the transcriptome. Mol. Cell. 2019;75:631-643.e638.
Not in our library10.1016/j.molcel.2019.06.006
88.
Drazkowska K, et al. 2′-O-Methylation of the second transcribed nucleotide within the mRNA 5′ cap impacts the protein production level in a cell-specific manner and contributes to RNA immune evasion. Nucleic Acids Res. 2022;50:9051-9071.
Not in our library10.1093/nar/gkac722
89.
Zhou H, et al. Evolution of a reverse transcriptase to map N(1)-methyladenosine in human messenger RNA. Nat. Methods. 2019;16:1281-1288.
Not in our library10.1038/s41592-019-0550-4
90.
Dunn DB. The occurrence of 1-methyladenine in ribonucleic acid. Biochim. Biophys. Acta. 1961;46:198-200.
Not in our library10.1016/0006-3002(61)90668-0
91.
Furuse Y. RNA modifications in genomic RNA of influenza A virus and the relationship between RNA modifications and viral infection. Int J. Mol. Sci. 2021;22:9127.
Not in our library10.3390/ijms22179127
92.
Chujo T, Suzuki T. Trmt61B is a methyltransferase responsible for 1-methyladenosine at position 58 of human mitochondrial tRNAs. RNA. 2012;18:2269-2276.
Not in our library10.1261/rna.035600.112
93.
Vilardo E, et al. A subcomplex of human mitochondrial RNase P is a bifunctional methyltransferase - extensive moonlighting in mitochondrial tRNA biogenesis (vol 40, pg 11583, 2012). Nucleic Acids Res. 2018;46:11126-11127.
Not in our library10.1093/nar/gky931
94.
Wang MX, et al. Crystal structure of the two-subunit tRNA m(1)A58 methyltransferase TRM6-TRM61 from Saccharomyces cerevisiae. Sci. Rep. 2016;6:32562.
Not in our library10.1038/srep32562
95.
Mitochondrial 16S rRNA Is Methylated by tRNA Methyltransferase TRMT61B in All Vertebrates · 2016
Corrected
96.
Waku T, et al. NML-mediated rRNA base methylation links ribosomal subunit formation to cell proliferation in a p53-dependent manner. J. Cell Sci. 2016;129:2382-2393.
Not in our library10.1242/jcs.183723
97.
Liu F, et al. ALKBH1-mediated tRNA demethylation regulates translation. Cell. 2016;167:816-828.e816.
Not in our library10.1016/j.cell.2016.09.038
98.
Li XY, et al. Transcriptome-wide mapping reveals reversible and dynamic N-1-methyladenosine methylome. Nat. Chem. Biol. 2016;12:311.
Not in our library10.1038/nchembio.2040
99.
Chen Z, et al. Transfer RNA demethylase ALKBH3 promotes cancer progression via induction of tRNA-derived small RNAs. Nucleic Acids Res. 2019;47:2533-2545.
Not in our library10.1093/nar/gky1250
100.
Zhang LS, et al. ALKBH7-mediated demethylation regulates mitochondrial polycistronic RNA processing. Nat. Cell Biol. 2021;23:684-691.
Not in our library10.1038/s41556-021-00709-7
101.
Safra M, et al. The m1A landscape on cytosolic and mitochondrial mRNA at single-base resolution. Nature. 2017;551:251-255.
Not in our library10.1038/nature24456
102.
Dai XX, Wang TL, Gonzalez G, Wang YS. Identification of YTH domain-containing proteins as the readers for N1-methyladenosine in RNA. Anal. Chem. 2018;90:6380-6384.
Not in our library10.1021/acs.analchem.8b01703
103.
Voigts-Hoffmann F, et al. A methyl group controls conformational equilibrium in human mitochondrial tRNA(Lys). J. Am. Chem. Soc. 2007;129:13382-13383.
Not in our library10.1021/ja075520+
104.
AlkB homolog 3-mediated tRNA demethylation promotes protein synthesis in cancer cells · 2017
No notice
105.
Dominissini D, et al. The dynamic N(1)-methyladenosine methylome in eukaryotic messenger RNA. Nature. 2016;530:441-446.
Not in our library10.1038/nature16998
106.
Zhou HQ, et al. m(1)A and m(1)G disrupt A-RNA structure through the intrinsic instability of Hoogsteen base pairs. Nat. Struct. Mol. Biol. 2016;23:803-810.
Not in our library10.1038/nsmb.3270
107.
Sharma S, et al. A single N-1-methyladenosine on the large ribosomal subunit rRNA impacts locally its structure and the translation of key metabolic enzymes. Sci. Rep. 2018;8:11904.
Not in our library10.1038/s41598-018-30383-z
108.
m1A Post‐Transcriptional Modification in tRNAs · 2017
No notice
109.
Eukaryotic 5-methylcytosine (m5C) RNA Methyltransferases: Mechanisms, Cellular Functions, and Links to Disease · 2019
No notice
110.
Amos H, Korn M. 5-Methyl cytosine in the RNA of Escherichia coli. Biochim. Biophys. Acta. 1958;29:444-445.
Not in our library10.1016/0006-3002(58)90214-2
111.
Chi L, Delgado-Olguin P. Expression of NOL1/NOP2/sun domain (Nsun) RNA methyltransferase family genes in early mouse embryogenesis. Gene Expr. Patterns. 2013;13:319-327.
Not in our library10.1016/j.gep.2013.06.003
112.
Yang Y, et al. RNA 5-methylcytosine facilitates the maternal-to-zygotic transition by preventing maternal mRNA decay. Mol. Cell. 2019;75:1188-1202 e1111.
Not in our library10.1016/j.molcel.2019.06.033
113.
Zou F, et al. Drosophila YBX1 homolog YPS promotes ovarian germ line stem cell development by preferentially recognizing 5-methylcytosine RNAs. Proc. Natl Acad. Sci. USA. 2020;117:3603-3609.
Not in our library10.1073/pnas.1910862117
114.
Sharma S, et al. Yeast Nop2 and Rcm1 methylate C2870 and C2278 of the 25S rRNA, respectively. Nucleic Acids Res. 2013;41:9062-9076.
Not in our library10.1093/nar/gkt679
115.
Schosserer M, et al. Methylation of ribosomal RNA by NSUN5 is a conserved mechanism modulating organismal lifespan. Nat Commun. 2016;7:11530.
Not in our library10.1038/ncomms11530
116.
Brzezicha B, et al. Identification of human tRNA:m5C methyltransferase catalysing intron-dependent m5C formation in the first position of the anticodon of the pre-tRNA Leu (CAA). Nucleic Acids Res. 2006;34:6034-6043.
Not in our library10.1093/nar/gkl765
117.
Haag S, et al. NSUN6 is a human RNA methyltransferase that catalyzes formation of m(5)C72 in specific tRNAs. RNA. 2015;21:1532-1543.
Not in our library10.1261/rna.051524.115
118.
Goll MG, et al. Methylation of tRNAAsp by the DNA methyltransferase homolog Dnmt2. Science. 2006;311:395-398.
Not in our library10.1126/science.1120976
119.
Nakano S, et al. NSUN3 methylase initiates 5-formylcytidine biogenesis in human mitochondrial tRNA(Met). Nat. Chem. Biol. 2016;12:546.
Not in our library10.1038/nchembio.2099
120.
NSUN4 Is a Dual Function Mitochondrial Protein Required for Both Methylation of 12S rRNA and Coordination of Mitoribosomal Assembly · 2014
No notice
121.
Camara Y, et al. MTERF4 regulates translation by targeting the methyltransferase NSUN4 to the mammalian mitochondrial ribosome. Cell Metab. 2011;13:527-539.
Not in our library10.1016/j.cmet.2011.04.002
122.
Khoddami V, Yerra A, Cairns BR. Experimental approaches for target profiling of RNA cytosine methyltransferases. Method Enzymol. 2015;560:273-296.
Not in our library10.1016/bs.mie.2015.03.008
123.
Hussain S, et al. The mouse cytosine-5 RNA methyltransferase NSun2 is a component of the chromatoid body and required for testis differentiation. Mol. Cell Biol. 2013;33:1561-1570.
Not in our library10.1128/mcb.01523-12
124.
Aguilo F, et al. Deposition of 5-methylcytosine on enhancer RNAs enables the coactivator function of PGC-1alpha. Cell Rep. 2016;14:479-492.
Not in our library10.1016/j.celrep.2015.12.043
125.
The role of m6A, m5C and Ψ RNA modifications in cancer: Novel therapeutic opportunities · 2021
No notice
126.
Arguello AE, et al. Reactivity-dependent profiling of RNA 5-methylcytidine dioxygenases. Nat. Commun. 2022;13:4176.
Not in our library10.1038/s41467-022-31876-2
127.
Kawarada L, et al. ALKBH1 is an RNA dioxygenase responsible for cytoplasmic and mitochondrial tRNA modifications. Nucleic Acids Res. 2017;45:7401-7415.
Not in our library10.1093/nar/gkx354
128.
Fu L, et al. Tet-mediated formation of 5-hydroxymethylcytosine in RNA. J. Am. Chem. Soc. 2014;136:11582-11585.
Not in our library10.1021/ja505305z
129.
Dominissini D, Rechavi G. 5-methylcytosine mediates nuclear export of mRNA. Cell Res. 2017;27:717-719.
Not in our library10.1038/cr.2017.73
130.
Dai X, et al. YTHDF2 binds to 5-methylcytosine in RNA and modulates the maturation of ribosomal RNA. Anal. Chem. 2020;92:1346-1354.
Not in our library10.1021/acs.analchem.9b04505
131.
Zhang X, et al. The tRNA methyltransferase NSun2 stabilizes p16INK(4) mRNA by methylating the 3′-untranslated region of p16. Nat. Commun. 2012;3:712.
Not in our library10.1038/ncomms1692
132.
Hussain S, et al. NSun2-mediated cytosine-5 methylation of vault noncoding Rna determines its processing into regulatory small RNAs. Cell Rep. 2013;4:255-261.
Not in our library10.1016/j.celrep.2013.06.029
133.
Liu YH, et al. mRNA m5C controls adipogenesis by promoting CDKN1A mRNA export and translation. RNA Biol. 2021;18:711-721.
Not in our library10.1080/15476286.2021.1980694
134.
Arango D, et al. Acetylation of cytidine in mRNA promotes translation efficiency. Cell. 2018;175:1872-1886.e1824.
Not in our library10.1016/j.cell.2018.10.030
135.
Meier J. Dynamic RNA acetylation revealed by quantitative cross-evolutionary mapping. J. Biol. Chem. 2023;299:S654-S654.
Not in our library10.1016/j.jbc.2023.104210
136.
Bortolin-Cavaille ML, et al. Probing small ribosomal subunit RNA helix 45 acetylation across eukaryotic evolution. Nucleic Acids Res. 2022;50:6284-6299.
Not in our library10.1093/nar/gkac404
137.
Acetyltransferase NAT10 regulates the Wnt/β-catenin signaling pathway to promote colorectal cancer progression via ac4C acetylation of KIF23 mRNA · 2022
No notice
138.
RNA modifications: importance in immune cell biology and related diseases · 2022
No notice
139.
Ikeuchi Y, Kitahara K, Suzuki T. The RNA acetyltransferase driven by ATP hydrolysis synthesizes N4-acetylcytidine of tRNA anticodon. EMBO J. 2008;27:2194-2203.
Not in our library10.1038/emboj.2008.154
140.
Sharma S, et al. Yeast Kre33 and human NAT10 are conserved 18S rRNA cytosine acetyltransferases that modify tRNAs assisted by the adaptor Tan1/THUMPD1. Nucleic Acids Res. 2015;43:2242-2258.
Not in our library10.1093/nar/gkv075
141.
Specialized box C/D snoRNPs act as antisense guides to target RNA base acetylation · 2017
No notice
142.
Whipple JM, et al. The yeast rapid tRNA decay pathway primarily monitors the structural integrity of the acceptor and T-stems of mature tRNA. Genes Dev. 2011;25:1173-1184.
Not in our library10.1101/gad.2050711
143.
Dominissini D, Rechavi G. N(4)-acetylation of cytidine in mRNA by NAT10 regulates stability and translation. Cell. 2018;175:1725-1727.
Not in our library10.1016/j.cell.2018.11.037
144.
Arango D, et al. Direct epitranscriptomic regulation of mammalian translation initiation through N4-acetylcytidine. Mol. Cell. 2022;82:2797-2814.e2711.
Not in our library10.1016/j.molcel.2022.05.016
145.
Ramanathan A, Robb GB, Chan SH. mRNA capping: biological functions and applications. Nucleic Acids Res. 2016;44:7511-7526.
Not in our library10.1093/nar/gkw551
146.
Zhang LS, et al. Transcriptome-wide mapping of internal N-7-methylguanosine methylome in mammalian mRNA. Mol. Cell. 2019;74:1304.
Not in our library10.1016/j.molcel.2019.03.036
147.
Alexandrov A, Martzen MR, Phizicky EM. Two proteins that form a complex are required for 7-methylguanosine modification of yeast tRNA. RNA. 2002;8:1253-1266.
Not in our library10.1017/s1355838202024019
148.
Alexandrov A, Grayhack EJ, Phizicky EM. tRNA m(7)G methyltransferase Trm8p/Trm82p: evidence linking activity to a growth phenotype and implicating Trm82p in maintaining levels of active Trm8p. RNA. 2005;11:821-830.
Not in our library10.1261/rna.2030705
149.
Trotman JB, Giltmier AJ, Mukherjee C, Schoenberg DR. RNA guanine-7 methyltransferase catalyzes the methylation of cytoplasmically recapped RNAs. Nucleic Acids Res. 2017;45:10726-10739.
Not in our library10.1093/nar/gkx801
150.
Haag S, Kretschmer J, Bohnsack MT. WBSCR22/Merm1 is required for late nuclear pre-ribosomal RNA processing and mediates N-7-methylation of G1639 in human 18S rRNA. RNA. 2015;21:180-187.
Not in our library10.1261/rna.047910.114
151.
Monecke T, Dickmanns A, Ficner R. Structural basis for m7G-cap hypermethylation of small nuclear, small nucleolar and telomerase RNA by the dimethyltransferase TGS1. Nucleic Acids Res. 2009;37:3865-3877.
Not in our library10.1093/nar/gkp249
152.
Mars JC, Ghram M, Culjkovic-Kraljacic B, Borden KLB. The cap-binding complex CBC and the eukaryotic translation factor eIF4E: co-conspirators in cap-dependent RNA maturation and translation. Cancers. 2021;13:24.
Not in our library10.3390/cancers13246185
153.
Galloway A, et al. Upregulation of RNA cap methyltransferase RNMT drives ribosome biogenesis during T cell activation. Nucleic Acids Res. 2021;49:6722-6738.
Not in our library10.1093/nar/gkab465
154.
Zhang LS, et al. Transcriptome-wide mapping of internal N(7)-methylguanosine methylome in mammalian mRNA. Mol. Cell. 2019;74:1304-1316.e1308.
Not in our library10.1016/j.molcel.2019.03.036
155.
Lin SB, et al. Mettl1/Wdr4-mediated m7G tRNA methylome is required for normal mRNA translation and embryonic stem cell self-renewal and differentiation. Mol. Cell. 2018;71:244.
Not in our library10.1016/j.molcel.2018.06.001
156.
Figaro S, et al. Trm112 is required for Bud23-mediated methylation of the 18S rRNA at position G1575. Mol. Cell Biol. 2012;32:2254-2267.
Not in our library10.1128/mcb.06623-11
157.
METTL1 Promotes let-7 MicroRNA Processing via m7G Methylation · 2019
No notice
158.
Zhao BS, He C. Pseudouridine in a new era of RNA modifications. Cell Res. 2015;25:153-154.
Not in our library10.1038/cr.2014.143
159.
Karijolich J, Yi CQ, Yu YT. Transcriptome-wide dynamics of RNA pseudouridylation. Nat. Rev. Mol. Cell Biol. 2015;16:581-585.
Not in our library10.1038/nrm4040
160.
Henras A, et al. Accumulation of H/ACA snoRNPs depends on the integrity of the conserved central domain of the RNA-binding protein Nhp2p. Nucleic Acids Res. 2001;29:2733-2746.
Not in our library10.1093/nar/29.13.2733
161.
Penzo M, et al. RNA pseudouridylation in physiology and medicine: for better and for worse. Genes. 2017;8:301.
Not in our library10.3390/genes8110301
162.
Song JH, et al. Differential roles of human PUS10 in miRNA processing and tRNA pseudouridylation. Nat. Chem. Biol. 2020;16:160.
Not in our library10.1038/s41589-019-0420-5
163.
Purchal MK, et al. Pseudouridine synthase 7 is an opportunistic enzyme that binds and modifies substrates with diverse sequences and structures. Proc. Natl Acad. Sci. USA. 2022;119:e2109708119.
Not in our library10.1073/pnas.2109708119
164.
Role of main RNA modifications in cancer: N6-methyladenosine, 5-methylcytosine, and pseudouridine · 2022
No notice
165.
Pseudouridine-modified tRNA fragments repress aberrant protein synthesis and predict leukaemic progression in myelodysplastic syndrome · 2022
No notice
166.
Karikó K, et al. Incorporation of pseudouridine Into mRNA yields superior nonimmunogenic vector with increased translational capacity and biological stability. Mol. Ther. 2008;16:1833-1840.
Not in our library10.1038/mt.2008.200
167.
Carlile TM, et al. Pseudouridine profiling reveals regulated mRNA pseudouridylation in yeast and human cells. Nature. 2014;515:143-146.
Not in our library10.1038/nature13802
168.
King TH, Liu B, McCully RR, Fournier MJ. Ribosome structure and activity are altered in cells lacking snoRNPs that form pseudouridines in the peptidyl transferase center. Mol. Cell. 2003;11:425-435.
Not in our library10.1016/s1097-2765(03)00040-6
169.
Jack K, et al. rRNA pseudouridylation defects affect ribosomal ligand binding and translational fidelity from yeast to human cells. Mol. Cell. 2011;44:660-666.
Not in our library10.1016/j.molcel.2011.09.017
170.
Zhao X, Yu YT. Pseudouridines in and near the branch site recognition region of U2 snRNA are required for snRNP biogenesis and pre-mRNA splicing in Xenopus oocytes. RNA. 2004;10:681-690.
Not in our library10.1261/rna.5159504
171.
Yang C, McPheeters DS, Yu YT. Psi35 in the branch site recognition region of U2 small nuclear RNA is important for pre-mRNA splicing in Saccharomyces cerevisiae. J. Biol. Chem. 2005;280:6655-6662.
Not in our library10.1074/jbc.m413288200
172.
The Critical Contribution of Pseudouridine to mRNA COVID-19 Vaccines · 2021
No notice
173.
Benne R, et al. Major transcript of the frameshifted coxII gene from trypanosome mitochondria contains four nucleotides that are not encoded in the DNA. Cell. 1986;46:819-826.
Not in our library10.1016/0092-8674(86)90063-2
174.
A novel type of RNA editing occurs in the mitochondrial tRNAs of the centipede Lithobius forficatus · 2000
Not checked
175.
Decatur WA, Fournier MJ. RNA-guided nucleotide modification of ribosomal and other RNAs. J. Biol. Chem. 2003;278:695-698.
Not in our library10.1074/jbc.r200023200
176.
Choudhury Y, et al. Attenuated adenosine-to-inosine editing of microRNA-376a* promotes invasiveness of glioblastoma cells. J. Clin. Investig. 2012;122:4059-4076.
Not in our library10.1172/jci62925
177.
Wagner RW, Smith JE, Cooperman BS, Nishikura K. A double-stranded RNA unwinding activity introduces structural alterations by means of adenosine to inosine conversions in mammalian cells and Xenopus eggs. Proc. Natl Acad. Sci. USA. 1989;86:2647-2651.
Not in our library10.1073/pnas.86.8.2647
178.
Yang Y, Okada S, Sakurai M. Adenosine-to-inosine RNA editing in neurological development and disease. RNA Biol. 2021;18:999-1013.
Not in our library10.1080/15476286.2020.1867797
179.
Mannion NM, et al. The RNA-editing enzyme ADAR1 controls innate immune responses to RNA. Cell Rep. 2014;9:1482-1494.
Not in our library10.1016/j.celrep.2014.10.041
180.
RADAR: a rigorously annotated database of A-to-I RNA editing · 2013
No notice
181.
Yang WD, et al. Modulation of microRNA processing and expression through RNA editing by ADAR deaminases. Nat. Struct. Mol. Biol. 2006;13:13-21.
Not in our library10.1038/nsmb1041
182.
Nishikura K. Editor meets silencer: crosstalk between RNA editing and RNA interference. Nat. Rev. Mol. Cell Biol. 2006;7:919-931.
Not in our library10.1038/nrm2061
183.
Bass BL. RNA editing by adenosine deaminases that act on RNA. Annu Rev. Biochem. 2002;71:817-846.
Not in our library10.1146/annurev.biochem.71.110601.135501
184.
Bass BL, Weintraub H. A developmentally regulated activity that unwinds RNA duplexes. Cell. 1987;48:607-613.
Not in our library10.1016/0092-8674(87)90239-x
185.
Ryter JM, Schultz SC. Molecular basis of double-stranded RNA-protein interactions: structure of a dsRNA-binding domain complexed with dsRNA. EMBO J. 1998;17:7505-7513.
Not in our library10.1093/emboj/17.24.7505
186.
Chen CX, et al. A third member of the RNA-specific adenosine deaminase gene family, ADAR3, contains both single- and double-stranded RNA binding domains. RNA. 2000;6:755-767.
Not in our library10.1017/s1355838200000170
187.
Nishikura K, et al. Substrate specificity of the dsRNA unwinding/modifying activity. EMBO J. 1991;10:3523-3532.
Not in our library10.1002/j.1460-2075.1991.tb04916.x
188.
Vitali P, et al. ADAR2-mediated editing of RNA substrates in the nucleolus is inhibited by C/D small nucleolar RNAs. J. Cell Biol. 2005;169:745-753.
Not in our library10.1083/jcb.200411129
189.
Farajollahi S, Maas S. Molecular diversity through RNA editing: a balancing act. Trends Genet. 2010;26:221-230.
Not in our library10.1016/j.tig.2010.02.001
190.
Ota H, et al. ADAR1 forms a complex with dicer to promote MicroRNA processing and RNA-induced gene silencing. Cell. 2013;153:575-589.
Not in our library10.1016/j.cell.2013.03.024
191.
Chandel NS. Glycolysis. Cold Spring Harb. Perspect. Biol. 2021;13:5.
Not in our library10.1101/cshperspect.a040535
192.
Warburg O, Wind F, Negelein E. The metabolism of tumors in the body. J. Gen. Physiol. 1927;8:519-530.
Not in our library10.1085/jgp.8.6.519
193.
The return of metabolism: biochemistry and physiology of the pentose phosphate pathway · 2014
No notice
194.
Grochowski LL, Xu H, White RH. Ribose-5-phosphate biosynthesis in Methanocaldococcus jannaschii occurs in the absence of a pentose-phosphate pathway. J. Bacteriol. 2005;187:7382-7389.
Not in our library10.1128/jb.187.21.7382-7389.2005
195.
Han HS, et al. Regulation of glucose metabolism from a liver-centric perspective. Exp. Mol. Med. 2016;48:e218.
Not in our library10.1038/emm.2015.122
196.
Sun J, et al. PARP1 is upregulated by hyperglycemia Via N6-methyladenosine modification and promotes diabetic retinopathy. Discov. Med. 2022;34:115-129.
Not in our library
197.
De Jesus DF, et al. m6A mRNA methylation regulates human β-cell biology in physiological states and in type 2 diabetes. Nat. Metab. 2019;1:765-774.
Not in our library10.1038/s42255-019-0089-9
198.
Wang YQ, et al. m6A mRNA methylation controls functional maturation in neonatal murine β-cells. Diabetes. 2020;69:1708-1722.
Not in our library10.2337/db19-0906
199.
Regue L, et al. RNA m6A reader IMP2/IGF2BP2 promotes pancreatic beta-cell proliferation and insulin secretion by enhancing PDX1 expression. Mol. Metab. 2021;48:101209.
Not in our library10.1016/j.molmet.2021.101209
200.
Peng T, et al. LncRNA Airn alleviates diabetic cardiac fibrosis by inhibiting activation of cardiac fibroblasts via a m6A-IMP2-p53 axis. Biol. Direct. 2022;17:32.
Not in our library10.1186/s13062-022-00346-6
201.
METTL14 suppresses pyroptosis and diabetic cardiomyopathy by downregulating TINCR lncRNA · 2022
Corrected
202.
Khoshi A, et al. Association of Omentin rs2274907 and FTO rs9939609 gene polymorphisms with insulin resistance in Iranian individuals with newly diagnosed type 2 diabetes. Lipids Health Dis. 2019;18:142.
Not in our library10.1186/s12944-019-1085-5
203.
Hjort R, et al. Interaction between overweight and genotypes of HLA, TCF7L2, and FTO in relation to the risk of latent autoimmune diabetes in adults and type 2 diabetes. J. Clin. Endocr. Metab. 2019;104:4815-4826.
Not in our library10.1210/jc.2019-00183
204.
Nasser FA, et al. The association of the common fat mass and obesity associated gene polymorphisms with type 2 diabetes in obese Iraqi population. Diabetes Metab. Synd. 2019;13:2451-2455.
Not in our library10.1016/j.dsx.2019.06.024
205.
Yang Y, et al. Glucose is involved in the dynamic regulation of m6a in patients with type 2 diabetes. J. Clin. Endocr. Metab. 2019;104:665-673.
Not in our library10.1210/jc.2018-00619
206.
Peng SM, et al. Identification of entacapone as a chemical inhibitor of FTO mediating metabolic regulation through FOXO1. Sci. Transl. Med. 2019;11:eaau7116.
Not in our library10.1126/scitranslmed.aau7116
207.
Zhou J, et al. Methyladenosine guides mRNA alternative translation during integrated stress response. Mol. Cell. 2018;69:636.
Not in our library10.1016/j.molcel.2018.01.019
208.
Li K, et al. MicroRNA-214 suppresses gluconeogenesis by targeting activating transcriptional factor 4. J. Biol. Chem. 2015;290:8185-8195.
Not in our library10.1074/jbc.m114.633990
209.
Hu F, et al. MiR-495 regulates macrophage M1/M2 polarization and insulin resistance in high-fat diet-fed mice via targeting FTO. Pflug. Arch. 2019;471:1529-1537.
Not in our library10.1007/s00424-019-02316-w
210.
N6-methyladenosine regulates glycolysis of cancer cells through PDK4 · 2020
No notice
211.
N6-methyladenosine METTL3 promotes cervical cancer tumorigenesis and Warburg effect through YTHDF1/HK2 modification · 2020
No notice
212.
Ma L, et al. The essential roles of m(6)A RNA modification to stimulate ENO1-dependent glycolysis and tumorigenesis in lung adenocarcinoma. J. Exp. Clin. Cancer Res. 2022;41:36.
Not in our library10.1186/s13046-021-02200-5
213.
m6A-dependent glycolysis enhances colorectal cancer progression · 2020
No notice
214.
Chen HR, et al. RNA N-6-methyladenosine methyltransferase METTL3 facilitates colorectal cancer by activating the m(6)A-GLUT1-mTORC1 axis and is a therapeutic target. Gastroenterology. 2021;160:1284.
Not in our library10.1053/j.gastro.2020.11.013
215.
Liu XS, et al. Overexpression of METTL3 associated with the metabolic status on (18)F-FDG PET/CT in patients with Esophageal Carcinoma. J. Cancer. 2020;11:4851-4860.
Not in our library10.7150/jca.44754
216.
Li FJ, et al. Glutamate from nerve cells promotes perineural invasion in pancreatic cancer by regulating tumor glycolysis through HK2 mRNA-m6A modification. Pharmacol. Res. 2023;187:106555.
Not in our library10.1016/j.phrs.2022.106555
217.
Zhang K, et al. N-6-methyladenosine-mediated LDHA induction potentiates chemoresistance of colorectal cancer cells through metabolic reprogramming. Theranostics. 2022;12:4802-4817.
Not in our library10.7150/thno.73746
218.
N6-Methyladenosine Modification of PTTG3P Contributes to Colorectal Cancer Proliferation via YAP1 · 2021
Not checked
219.
Wang Q, et al. METTL3-mediated m(6)A modification of HDGF mRNA promotes gastric cancer progression and has prognostic significance. Gut. 2020;69:1193-1205.
Not in our library10.1136/gutjnl-2019-319639
220.
Zhang Q, et al. METTL3-induced DLGAP1-AS2 promotes non-small cell lung cancer tumorigenesis through m(6)A/c-Myc-dependent aerobic glycolysis. Cell Cycle. 2022;21:2602-2614.
Not in our library10.1080/15384101.2022.2105885
221.
METTL3 promotes tumour development by decreasing APC expression mediated by APC mRNA N6-methyladenosine-dependent YTHDF binding · 2021
Corrected
222.
Yang N, et al. HBXIP drives metabolic reprogramming in hepatocellular carcinoma cells via METTL3-mediated m6A modification of HIF-1alpha. J. Cell Physiol. 2021;236:3863-3880.
Not in our library10.1002/jcp.30128
223.
Xu Y, et al. The N6-methyladenosine METTL3 regulates tumorigenesis and glycolysis by mediating m6A methylation of the tumor suppressor LATS1 in breast cancer. J. Exp. Clin. Cancer Res. 2023;42:10.
Not in our library10.1186/s13046-022-02581-1
224.
Xu W, et al. m6A RNA methylation-mediated NDUFA4 promotes cell proliferation and metabolism in gastric cancer. Cell Death Dis. 2022;13:715.
Not in our library10.1038/s41419-022-05132-w
225.
Cai J, et al. METTL3 promotes glycolysis and cholangiocarcinoma progression by mediating the m6A modification of AKR1B10. Cancer Cell Int. 2022;22:385.
Not in our library10.1186/s12935-022-02809-2
226.
Chen Z, et al. Non-SMC condensin I complex subunit H participates in anti-programmed cell death-1 resistance of clear cell renal cell carcinomas. Cell Prolif. 2023;56:e13400.
Not in our library10.1111/cpr.13400
227.
Xue L, et al. m(6)A transferase METTL3-induced lncRNA ABHD11-AS1 promotes the Warburg effect of non-small-cell lung cancer. J. Cell Physiol. 2021;236:2649-2658.
Not in our library10.1002/jcp.30023
228.
Liu J, Yuan JF, Wang YZ. METTL3-stabilized lncRNA SNHG7 accelerates glycolysis in prostate cancer via SRSF1/c-Myc axis. Exp. Cell Res. 2022;416:113149.
Not in our library10.1016/j.yexcr.2022.113149
229.
Liu ZH, et al. N6-methyladenosine-modified circular RNA QSOX1 promotes colorectal cancer resistance to anti-CTLA-4 therapy through induction of intratumoral regulatory T cells. Drug Resist. Update. 2022;65:100886.
Not in our library10.1016/j.drup.2022.100886
230.
He Y, et al. Linc-UROD stabilizes ENO1 and PKM to strengthen glycolysis, proliferation and migration of pancreatic cancer cells. Transl. Oncol. 2023;27:101583.
Not in our library10.1016/j.tranon.2022.101583
231.
Hou Y, et al. METTL14 modulates glycolysis to inhibit colorectal tumorigenesis in p53-wild-type cells. EMBO Rep. 2023;24:e56325.
Not in our library10.15252/embr.202256325
232.
Du L, et al. USP48 is upregulated by Mettl14 to attenuate hepatocellular carcinoma via regulating SIRT6 stabilization. Cancer Res. 2021;81:3822-3834.
Not in our library10.1158/0008-5472.can-20-4163
233.
Downregulated METTL14 accumulates BPTF that reinforces super-enhancers and distal lung metastasis via glycolytic reprogramming in renal cell carcinoma · 2021
No notice
234.
Lin JX, et al. m6A methylation mediates LHPP acetylation as a tumour aerobic glycolysis suppressor to improve the prognosis of gastric cancer. Cell Death Dis. 2022;13:463.
Not in our library10.1038/s41419-022-04859-w
235.
Yu H, et al. N-6-methyladenosine (m(6)A) methyltransferase WTAP accelerates the Warburg effect of gastric cancer through regulating HK2 stability. Biomed. Pharmacother. 2021;133:111075.
Not in our library10.1016/j.biopha.2020.111075
236.
Lyu YY, et al. HIF-1 alpha Regulated WTAP overexpression promoting the Warburg effect of ovarian cancer by m6A-dependent manner. J. Immunol. Res. 2022;2022:6130806.
Not in our library10.1155/2022/6130806
237.
Ou BC, et al. C5aR1-positive neutrophils promote breast cancer glycolysis through WTAP-dependent m6A methylation of ENO1. Cell Death Dis. 2021;12:737.
Not in our library10.1038/s41419-021-04028-5
238.
Zhang Y, et al. WTAP mediates FOXP3 mRNA stability to promote SMARCE1 expression and augment glycolysis in colon adenocarcinoma. Mamm. Genome. 2022;33:654-671.
Not in our library10.1007/s00335-022-09962-z
239.
Li H, Li C, Zhang B, Jiang H. Lactoferrin suppresses the progression of colon cancer under hyperglycemia by targeting WTAP/m(6)A/NT5DC3/HKDC1 axis. J. Transl. Med. 2023;21:156.
Not in our library10.1186/s12967-023-03983-1
240.
Li Y, et al. N(6)-methyladenosine methyltransferase KIAA1429 elevates colorectal cancer aerobic glycolysis via HK2-dependent manner. Bioengineered. 2022;13:11923-11932.
Not in our library10.1080/21655979.2022.2065952
241.
Yang DS, et al. m(6)A transferase KIAA1429-stabilized LINC00958 accelerates gastric cancer aerobic glycolysis through targeting GLUT1. IUBMB Life. 2021;73:1325-1333.
Not in our library10.1002/iub.2545
242.
Yang F, et al. Circ-CTNNB1 drives aerobic glycolysis and osteosarcoma progression via m6A modification through interacting with RBM15. Cell Proliferat. 2023;56:1.
Not in our library10.1111/cpr.13344
243.
Wang QB, et al. ZC3H13 inhibits the progression of hepatocellular carcinoma through m(6)A-PKM2-mediated glycolysis and enhances chemosensitivity. J Oncol. 2021;2021:1328444.
Not in our library10.1155/2021/1328444
244.
Li J, et al. m6A demethylase FTO promotes hepatocellular carcinoma tumorigenesis via mediating PKM2 demethylation. Am. J. Transl. Res. 2019;11:6084-6092.
Not in our library
245.
Li XD, et al. Long noncoding RNA just proximal to X-inactive specific transcript facilitates aerobic glycolysis and temozolomide chemoresistance by promoting stability of PDK1 mRNA in an m6A-dependent manner in glioblastoma multiforme cells. Cancer Sci. 2021;112:4543-4552.
Not in our library10.1111/cas.15072
246.
Yanar S, et al. Proteomics analysis of meclofenamic acid-treated small cell lung carcinoma cells revealed changes in cellular energy metabolism for cancer cell survival. J. Biochem. Mol. Toxic. 2023;37:4.
Not in our library10.1002/jbt.23289
247.
Qing Y, et al. R-2-hydroxyglutarate attenuates aerobic glycolysis in leukemia by targeting the FTO/m(6)A/PFKP/LDHB axis. Mol. Cell. 2021;81:922.
Not in our library10.1016/j.molcel.2020.12.026
248.
Liu Y, et al. Tumors exploit FTO-mediated regulation of glycolytic metabolism to evade immune surveillance. Cell Metab. 2021;33:1221.
Not in our library10.1016/j.cmet.2021.04.001
249.
Liu CY, et al. E6E7 regulates the HK2 expression in cervical cancer via GSK3B/FTO signal. Arch. Biochem. Biophys. 2022;729:109389.
Not in our library10.1016/j.abb.2022.109389
250.
WNT/β-catenin-suppressed FTO expression increases m6A of c-Myc mRNA to promote tumor cell glycolysis and tumorigenesis · 2021
No notice
251.
FTO suppresses glycolysis and growth of papillary thyroid cancer via decreasing stability of APOE mRNA in an N6-methyladenosine-dependent manner · 2022
No notice
252.
Liu Z, Chen Y, Wang L, Ji S. ALKBH5 promotes the proliferation of glioma cells via enhancing the mRNA stability of G6PD. Neurochem. Res. 2021;46:3003-3011.
Not in our library10.1007/s11064-021-03408-9
253.
Liu H, et al. ALKBH5-mediated m6A demethylation of GLUT4 mRNA promotes glycolysis and resistance to HER2-targeted therapy in breast cancer. Cancer Res. 2022;82:3974-3986.
Not in our library10.1158/0008-5472.can-22-0800
254.
Ji X, et al. ALKBH5-induced circular RNA NRIP1 promotes glycolysis in thyroid cancer cells by targeting PKM2. Cancer Sci. 2023;114:2318-2334.
Not in our library10.1111/cas.15772
255.
Zhao L, et al. UBR7 inhibits HCC tumorigenesis by targeting Keap1/Nrf2/Bach1/HK2 and glycolysis. J. Exp. Clin. Cancer Res. 2022;41:330.
Not in our library10.1186/s13046-022-02528-6
256.
Wang YQ, et al. HLA complex P5 upregulation is correlated with poor prognosis and tumor progression in esophageal squamous cell carcinoma. Bioengineered. 2022;13:9301-9311.
Not in our library10.1080/21655979.2022.2051854
257.
Sheng H, et al. YTH domain family 2 promotes lung cancer cell growth by facilitating 6-phosphogluconate dehydrogenase mRNA translation. Carcinogenesis. 2020;41:541-550.
Not in our library10.1093/carcin/bgz152
258.
Chen BX, et al. N6-methyladenosine modification of circ_0003215 suppresses the pentose phosphate pathway and malignancy of colorectal cancer through the miR-663b/DLG4/G6PD axis. Cell Death Dis. 2022;13:804.
Not in our library10.1038/s41419-022-05245-2
259.
Li HY. Downregulation of microRNA-6125 promotes colorectal cancer growth through YTHDF2-dependent recognition of N6-methyladenosine-modified GSK3 beta. Clin. Transl. Med. 2022;12:e1085.
Not in our library10.1002/ctm2.602
260.
Hypoxia-induced lncRNA STEAP3-AS1 activates Wnt/β-catenin signaling to promote colorectal cancer progression by preventing m6A-mediated degradation of STEAP3 mRNA · 2022
No notice
261.
Zhou R, et al. A functional loop between YTH domain family protein YTHDF3 mediated m(6)A modification and phosphofructokinase PFKL in glycolysis of hepatocellular carcinoma. J. Exp. Clin. Cancer Res. 2022;41:334.
Not in our library10.1186/s13046-022-02538-4
262.
A reciprocal feedback between N6-methyladenosine reader YTHDF3 and lncRNA DICER1-AS1 promotes glycolysis of pancreatic cancer through inhibiting maturation of miR-5586-5p · 2022
Not checked
263.
Liu DY, et al. N-6-methyladenosine reader YTHDF3 contributes to the aerobic glycolysis of osteosarcoma through stabilizing PGK1 stability. J. Cancer Res. Clin. 2022;149:4601-4610.
Not in our library10.1007/s00432-022-04337-y
264.
Luo F, Lin K. N-6-methyladenosine (m(6)A) reader IGF2BP1 accelerates gastric cancer aerobic glycolysis in c-Myc-dependent manner. Exp. Cell Res. 2022;417:113176.
Not in our library10.1016/j.yexcr.2022.113176
265.
Yuan B, Zhou J. N6-methyladenosine (m6A) reader IGF2BP1 facilitates clear-cell renal cell carcinoma aerobic glycolysis. PeerJ. 2023;11:e14591.
Not in our library10.7717/peerj.14591
266.
Xu K, Dai XJ, Wu JK, Wen K. N-6-methyladenosine (m(6)A) reader IGF2BP2 stabilizes HK2 stability to accelerate the Warburg effect of oral squamous cell carcinoma progression. J. Cancer Res. Clin. 2022;148:3375-3384.
Not in our library10.1007/s00432-022-04093-z
267.
HPV E6/E7 promotes aerobic glycolysis in cervical cancer by regulating IGF2BP2 to stabilize m 6 A-MYC expression · 2022
No notice
268.
Ye Y, et al. lncRNA miR4458HG modulates hepatocellular carcinoma progression by activating m6A-dependent glycolysis and promoting the polarization of tumor-associated macrophages. Cell Mol. Life Sci. 2023;80:99.
Not in our library10.1007/s00018-023-04741-8
269.
Cui YM, et al. m(6)A-modified circFOXK2 targets GLUT1 to accelerate oral squamous cell carcinoma aerobic glycolysis. Cancer Gene Ther. 2023;30:163-171.
Not in our library10.1038/s41417-022-00526-6
270.
Xu TP, et al. LOC101929709 promotes gastric cancer progression by aiding LIN28B to stabilize c-MYC mRNA. Gastr. Cancer. 2023;26:169-186.
Not in our library10.1007/s10120-022-01348-z
271.
Wu YM, et al. RNA m(1)A methylation regulates glycolysis of cancer cells through modulating ATP5D. Proc. Natl Acad. Sci. USA. 2022;119:e2119038119.
Not in our library10.1073/pnas.2119038119
272.
Wang JZ, et al. The role of the HIF-1 alpha/ALYREF/PKM2 axis in glycolysis and tumorigenesis of bladder cancer. Cancer Commun. 2021;41:560-575.
Not in our library10.1002/cac2.12158
273.
Xu FS, et al. N7-methylguanosine regulatory genes well represented by METTL1 define vastly different prognostic, immune and therapy landscapes in adrenocortical carcinoma. Am. J. Cancer Res. 2023;13:538.
Not in our library
274.
Zhang BJ, et al. m6A demethylase FTO attenuates cardiac dysfunction by regulating glucose uptake and glycolysis in mice with pressure overload-induced heart failure. Signal Transduct. Tar. 2021;6:377.
Not in our library10.1038/s41392-021-00699-w
275.
Zhou Y, et al. METTL3 boosts glycolysis and cardiac fibroblast proliferation by increasing AR methylation. Int. J. Biol. Macromol. 2022;223:899-915.
Not in our library10.1016/j.ijbiomac.2022.11.042
276.
Cai W, et al. METTL3-dependent glycolysis regulates dental pulp stem cell differentiation. J. Dent. Res. 2022;101:580-589.
Not in our library10.1177/00220345211051594
277.
Jiao Y, Williams A, Wei N. Quercetin ameliorated insulin resistance via regulating METTL3-mediated N6-methyladenosine modification of PRKD2 mRNA in skeletal muscle and C2C12 myocyte cell line. Nutr. Metab. Cardiovasc. 2022;32:2655-2668.
Not in our library10.1016/j.numecd.2022.06.019
278.
Fahy E, et al. Update of the LIPID MAPS comprehensive classification system for lipids. J. Lipid Res. 2009;50:S9-14,.
Not in our library10.1194/jlr.r800095-jlr200
279.
Ahmed MH, Byrne CD. Modulation of sterol regulatory element binding proteins (SREBPs) as potential treatments for non-alcoholic fatty liver disease (NAFLD). Drug Discov. Today. 2007;12:740-747.
Not in our library10.1016/j.drudis.2007.07.009
280.
Li L, et al. Differential requirement for de novo lipogenesis in cholangiocarcinoma and hepatocellular carcinoma of mice and humans. Hepatology. 2016;63:1900-1913.
Not in our library10.1002/hep.28508
281.
Luo J, Yang H, Song BL. Mechanisms and regulation of cholesterol homeostasis. Nat. Rev. Mol. Cell Biol. 2020;21:225-245.
Not in our library10.1038/s41580-019-0190-7
282.
m6A Regulators in Human Adipose Tissue - Depot-Specificity and Correlation With Obesity · 2021
Not checked
283.
METTL3 is essential for postnatal development of brown adipose tissue and energy expenditure in mice · 2020
No notice
284.
Xie W, et al. METTL3 inhibits hepatic insulin sensitivity via N6-methyladenosine modification of Fasn mRNA and promoting fatty acid metabolism. Biochem. Biophys. Res. Commun. 2019;518:120-126.
Not in our library10.1016/j.bbrc.2019.08.018
285.
Liu Q, et al. ZFP217 regulates adipogenesis by controlling mitotic clonal expansion in a METTL3-m(6)A dependent manner. RNA Biol. 2019;16:1785-1793.
Not in our library10.1080/15476286.2019.1658508
286.
Ningombam SS, et al. Differential distribution and association of FTO gene polymorphism with obesity: a cross-sectional study among two tribal populations of India with East-Asian ancestry. Gene. 2018;647:198-204.
Not in our library10.1016/j.gene.2018.01.009
287.
Hebbar P, et al. Variant rs1421085 associates with increased body weight, soft lean mass, and total body water through interaction with ghrelin and apolipoproteins in Arab population. Front. Genet. 2020;10:1411.
Not in our library10.3389/fgene.2019.01411
288.
Zhao X, et al. FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis. Cell Res. 2014;24:1403-1419.
Not in our library10.1038/cr.2014.151
289.
Wu R, et al. FTO regulates adipogenesis by controlling cell cycle progression via m(6)A-YTHDF2 dependent mechanism. Biochim. Biophys. Acta Mol. Cell Biol. Lipids. 2018;1863:1323-1330.
Not in our library10.1016/j.bbalip.2018.08.008
290.
Wu R, et al. Epigallocatechin gallate targets FTO and inhibits adipogenesis in an mRNA m(6)A-YTHDF2-dependent manner. Int. J. Obes. 2018;42:1378-1388.
Not in our library10.1038/s41366-018-0082-5
291.
Song T, et al. Zfp217 mediates m6A mRNA methylation to orchestrate transcriptional and post-transcriptional regulation to promote adipogenic differentiation. Nucleic Acids Res. 2019;47:6130-6144.
Not in our library10.1093/nar/gkz312
292.
Shen GS, et al. The GDF11-FTO-PPARγ axis controls the shift of osteoporotic MSC fate to adipocyte and inhibits bone formation during osteoporosis. BBA-Mol. Basis Dis. 2018;1864:3644-3654.
Not in our library10.1016/j.bbadis.2018.09.015
293.
Kruger N, et al. Loss of endothelial FTO antagonizes obesity-induced metabolic and vascular dysfunction. Circ. Res. 2020;126:232-242.
Not in our library10.1161/circresaha.119.315531
294.
Wu WC, et al. AMPK regulates lipid accumulation in skeletal muscle cells through FTO-dependent demethylation of N6-methyladenosine. Sci. Rep. 2017;7:41606.
Not in our library10.1038/srep41606
295.
Zhou XH, et al. The beneficial effects of betaine on dysfunctional adipose tissue and N6-methyladenosine mRNA methylation requires the AMP-activated protein kinase α1 subunit. J. Nutr. Biochem. 2015;26:1678-1684.
Not in our library10.1016/j.jnutbio.2015.08.014
296.
Jiang Q, et al. promotes adipogenesis in intramuscular preadipocytes an m6A-YTHDF1-dependent mechanism. FASEB J. 2019;33:2971-2981.
Not in our library10.1096/fj.201801393rrr
297.
Liu Q, et al. ZFP217 regulates adipogenesis by controlling mitotic clonal expansion in a METTL3-m6A dependent manner. RNA Biol. 2019;16:1785-1793.
Not in our library10.1080/15476286.2019.1658508
298.
Liu W, et al. ‘Micro-managers’ of hepatic lipid metabolism and NAFLD. Wiley Interdiscip. Rev. Rna. 2015;6:581-593.
Not in our library10.1002/wrna.1295
299.
Yang Y, et al. Dysregulated m6A modification promotes lipogenesis and development of non-alcoholic fatty liver disease and hepatocellular carcinoma. Mol. Ther. 2022;30:2342-2353.
Not in our library10.1016/j.ymthe.2022.02.021
300.
Peng Z, et al. METTL3-m(6)A-Rubicon axis inhibits autophagy in nonalcoholic fatty liver disease. Mol. Ther. 2022;30:932-946.
Not in our library10.1016/j.ymthe.2021.09.016
301.
Chen J, et al. FTO-dependent function of N6-methyladenosine is involved in the hepatoprotective effects of betaine on adolescent mice. J. Physiol. Biochem. 2015;71:405-413.
Not in our library10.1007/s13105-015-0420-1
302.
Guo J, et al. Fat mass and obesity-associated gene enhances oxidative stress and lipogenesis in nonalcoholic fatty liver disease. Dig. Dis. Sci. 2013;58:1004-1009.
Not in our library10.1007/s10620-012-2516-6
303.
Hu Y, et al. GR-mediated FTO transactivation induces lipid accumulation in hepatocytes via demethylation of m(6)A on lipogenic mRNAs. RNA Biol. 2020;17:930-942.
Not in our library10.1080/15476286.2020.1736868
304.
Sun LM, et al. Differential mechanisms regarding triclosan vs. bisphenol A and fluorene-9-bisphenol induced zebrafish lipid-metabolism disorders by RNA-seq. Chemosphere. 2020;251:126318.
Not in our library10.1016/j.chemosphere.2020.126318
305.
Hu Y, et al. GR-mediated FTO transactivation induces lipid accumulation in hepatocytes via demethylation of m6A on lipogenic mRNAs. RNA Biol. 2020;17:930-942.
Not in our library10.1080/15476286.2020.1736868
306.
Li S, et al. Exenatide ameliorates hepatic steatosis and attenuates fat mass and gene expression through PI3K signaling pathway in nonalcoholic fatty liver disease. Braz. J. Med. Biol. Res. 2018;51:e7299.
Not in our library10.1590/1414-431x20187299
307.
Gan X, et al. FTO promotes liver inflammation by suppressing m6A mRNA methylation of IL-17RA. Front. Oncol. 2022;12:989353.
Not in our library10.3389/fonc.2022.989353
308.
Wang HQ, et al. LINC01468 drives NAFLD-HCC progression through CUL4A-linked degradation of SHIP2. Cell Death Discov. 2022;8:499.
Not in our library10.1038/s41420-022-01234-8
309.
Yang JJ, et al. ALKBH5 ameliorated liver fibrosis and suppressed HSCs activation via triggering PTCH1 activation in an m6A dependent manner. Eur. J. Pharmacol. 2022;922:174900.
Not in our library10.1016/j.ejphar.2022.174900
310.
Sun RM, et al. The m6A reader YTHDF3-mediated PRDX3 translation alleviates liver fibrosis. Redox Biol. 2022;54:102378.
Not in our library10.1016/j.redox.2022.102378
311.
Libby P, Ridker PM, Hansson GK. Progress and challenges in translating the biology of atherosclerosis. Nature. 2011;473:317-325.
Not in our library10.1038/nature10146
312.
Back M, et al. Inflammation and its resolution in atherosclerosis: mediators and therapeutic opportunities. Nat. Rev. Cardiol. 2019;16:389-406.
Not in our library10.1038/s41569-019-0169-2
313.
Chen J, et al. Silencing METTL3 stabilizes atherosclerotic plaques by regulating the phenotypic transformation of vascular smooth muscle cells via the miR-375-3p/PDK1 axis. Cardiovasc. Drugs Ther. 2023;37:471-486.
Not in our library10.1007/s10557-022-07348-6
314.
Liu Y, et al. Methyltransferase-like 14 silencing relieves the development of atherosclerosis via m(6)A modification of p65 mRNA. Bioengineered. 2022;13:11832-11843.
Not in our library10.1080/21655979.2022.2031409
315.
Gong C, Fan Y, Liu J. METTL14 mediated m6A modification to LncRNA ZFAS1/ RAB22A: A novel therapeutic target for atherosclerosis. Int. J. Cardiol. 2021;328:177.
Not in our library10.1016/j.ijcard.2020.12.002
316.
Mo C, et al. Fat mass and obesity-associated protein attenuates lipid accumulation in macrophage foam cells and alleviates atherosclerosis in apolipoprotein E-deficient mice. J. Hypertens. 2017;35:810-821.
Not in our library10.1097/hjh.0000000000001255
317.
Yang Z, et al. Critical roles of FTO-mediated mRNA m6A demethylation in regulating adipogenesis and lipid metabolism: implications in lipid metabolic disorders. Genes Dis. 2022;9:51-61.
Not in our library10.1016/j.gendis.2021.01.005
318.
Ladanyi A, et al. Adipocyte-induced CD36 expression drives ovarian cancer progression and metastasis. Oncogene. 2018;37:2285-2301.
Not in our library10.1038/s41388-017-0093-z
319.
Doll S, et al. ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition. Nat. Chem. Biol. 2017;13:91-98.
Not in our library10.1038/nchembio.2239
320.
Hisano Y, Hla T. Bioactive lysolipids in cancer and angiogenesis. Pharm. Ther. 2019;193:91-98.
Not in our library10.1016/j.pharmthera.2018.07.006
321.
Liu PH, et al. m(6)A-induced lncDBET promotes the malignant progression of bladder cancer through FABP5-mediated lipid metabolism. Theranostics. 2022;12:6291-6307.
Not in our library10.7150/thno.71456
322.
Zhong X, et al. Circadian clock regulation of hepatic lipid metabolism by modulation of m(6)A mRNA methylation. Cell Rep. 2018;25:1816-1828 e1814.
Not in our library10.1016/j.celrep.2018.10.068
323.
Chen ZJ, et al. N6-methyladenosine-induced ERR. triggers chemoresistance of cancer cells through upregulation of ABCB1 and metabolic reprogramming. Theranostics. 2020;10:3382-3396.
Not in our library10.7150/thno.40144
324.
Peng H, et al. N(6)-methyladenosine (m(6)A) in 18S rRNA promotes fatty acid metabolism and oncogenic transformation. Nat. Metab. 2022;4:1041-1054.
Not in our library10.1038/s42255-022-00622-9
325.
Sun DL, et al. Fat mass and obesity-associated protein regulates lipogenesis via m(6)A modification in fatty acid synthase mRNA. Cell Biol. Int. 2021;45:334-344.
Not in our library10.1002/cbin.11490
326.
Duan XR, et al. m6A demethylase FTO promotes tumor progression via regulation of lipid metabolism in esophageal cancer. Cell Biosci. 2022;12:60.
Not in our library10.1186/s13578-022-00798-3
327.
Zhen L, Pan WY. ALKBH5 inhibits the SIRT3/ACC1 axis to regulate fatty acid metabolism via an m6A-IGF2BP1-dependent manner in cervical squamous cell carcinoma. Clin. Exp. Pharm. Pract. 2023;50:380-392.
Not in our library10.1111/1440-1681.13754
328.
Zhou B, et al. N-6-methyladenosine reader protein YT521-B homology domain-containing 2 suppresses liver steatosis by regulation of mRNA stability of lipogenic genes. Hepatology. 2021;73:91-103.
Not in our library10.1002/hep.31220
329.
EGFR/SRC/ERK-stabilized YTHDF2 promotes cholesterol dysregulation and invasive growth of glioblastoma · 2021
No notice
330.
Guo W, et al. M6A methylation of DEGS2, a key ceramide-synthesizing enzyme, is involved in colorectal cancer progression through ceramide synthesis. Oncogene. 2021;40:5913-5924.
Not in our library10.1038/s41388-021-01987-z
331.
Cheng Y, et al. Decoding m(6)A RNA methylome identifies PRMT6-regulated lipid transport promoting AML stem cell maintenance. Cell Stem Cell. 2023;30:69-85 e67.
Not in our library10.1016/j.stem.2022.12.003
332.
Jia YX, et al. Long non-coding RNA NEAT1 mediated RPRD1B stability facilitates fatty acid metabolism and lymph node metastasis via c-Jun/c-Fos/SREBP1 axis in gastric cancer. J. Exp. Clin. Cancer Res. 2022;41:287.
Not in our library10.1186/s13046-022-02449-4
333.
Guo HM, et al. m(6)A Reader HNRNPA2B1 promotes esophageal cancer progression via up-regulation of ACLY and ACC1. Front. Oncol. 2020;10:553045.
Not in our library10.3389/fonc.2020.553045
334.
Liu Y, et al. mRNA m(5)C inhibits adipogenesis and promotes myogenesis by respectively facilitating YBX2 and SMO mRNA export in ALYREF-m(5)C manner. Cell Mol. Life Sci. 2022;79:481.
Not in our library10.1007/s00018-022-04474-0
335.
Yang M, et al. NSUN2 promotes osteosarcoma progression by enhancing the stability of FABP5 mRNA via m(5)C methylation. Cell Death Dis. 2023;14:125.
Not in our library10.1038/s41419-023-05646-x
336.
Xu J, et al. RNA 5-methylcytosine regulators contribute to metabolism heterogeneity and predict prognosis in ovarian cancer. Front. Cell Dev. Biol. 2022;10:807786.
Not in our library10.3389/fcell.2022.807786
337.
N1-methyladenosine methylation in tRNA drives liver tumourigenesis by regulating cholesterol metabolism · 2021
No notice
338.
Courtney KD, et al. Isotope tracing of human clear cell renal cell carcinomas demonstrates suppressed glucose oxidation in vivo. Cell Metab. 2018;28:793-800.e792.
Not in our library10.1016/j.cmet.2018.07.020
339.
Mitochondrial metabolism and cancer · 2017
No notice
340.
Zhang X, et al. The m(6)A methyltransferase METTL3 modifies PGC-1alpha mRNA promoting mitochondrial dysfunction and oxLDL-induced inflammation in monocytes. J. Biol. Chem. 2021;297:101058.
Not in our library10.1016/j.jbc.2021.101058
341.
N6‐methyladenosine demethylase FTO suppresses clear cell renal cell carcinoma through a novel FTO ‐ PGC ‐1α signalling axis · 2019
No notice
342.
METTL3 promotes chemoresistance in small cell lung cancer by inducing mitophagy · 2023
No notice
343.
Liu XC, et al. Adenylate kinase 4 modulates the resistance of breast cancer cells to tamoxifen through an m(6)A-based epitranscriptomic mechanism. Mol. Ther. 2020;28:2593-2604.
Not in our library10.1016/j.ymthe.2020.09.007
344.
Hou HY. METTL3 promotes the proliferation and invasion of esophageal cancer cells partly through AKT signaling pathway. Pathol. Res. Pract. 2020;216:153087.
Not in our library10.1016/j.prp.2020.153087
345.
Sun KY, et al. METTL14-dependent maturation of pri-miR-17 regulates mitochondrial homeostasis and induces chemoresistance in colorectal cancer. Cell Death Dis. 2023;14:148.
Not in our library10.1038/s41419-023-05670-x
346.
Deng P, et al. Long-term cadmium exposure impairs cognitive function by activating lnc-Gm10532/m6A/FIS1 axis-mediated mitochondrial fission and dysfunction. Sci. Total Environ. 2023;858:159950.
Not in our library10.1016/j.scitotenv.2022.159950
347.
Du YD, et al. N6-methyladenosine demethylase FTO impairs hepatic ischemia-reperfusion injury via inhibiting Drp1-mediated mitochondrial fragmentation. Cell Death Dis. 2021;12:442.
Not in our library10.1038/s41419-021-03622-x
348.
Li N, et al. Gene characteristics and prognostic values of m(6)A RNA methylation regulators in nonsmall cell lung cancer. J. Health. Eng. 2021;2021:2257066.
Not in our library10.1155/2021/2257066
349.
Wang ZS, et al. Expression and prognostic potential of ribosome 18S RNA m(6)A methyltransferase METTL5 in gastric cancer. Cancer Cell Int. 2021;21:569.
Not in our library10.1186/s12935-021-02274-3
350.
Wang C, et al. Crosstalk of oxidative phosphorylation-related subtypes, establishment of a prognostic signature and immune infiltration characteristics in colorectal adenocarcinoma. Cancers. 2022;14:4503.
Not in our library10.3390/cancers14184503
351.
Yin R, et al. Differential m(6)A RNA landscapes across hematopoiesis reveal a role for IGF2BP2 in preserving hematopoietic stem cell function. Cell Stem Cell. 2022;29:149-159.e147.
Not in our library10.1016/j.stem.2021.09.014
352.
Sun L, et al. RNA-binding protein RALY reprogrammes mitochondrial metabolism via mediating miRNA processing in colorectal cancer. Gut. 2021;70:1698-1712.
Not in our library10.1136/gutjnl-2020-320652
353.
Li GW, Lu XF, Xu QQ, Jin YP. The FDX1 methylation regulatory mechanism in the malignant phenotype of glioma. Genomics. 2023;115:110601.
Not in our library10.1016/j.ygeno.2023.110601
354.
Jia C, et al. HNRNPA2B1-mediated m6A modification of TLR4 mRNA promotes progression of multiple myeloma. J. Transl. Med. 2022;20:537.
Not in our library10.1186/s12967-022-03750-8
355.
Curi R, et al. Molecular mechanisms of glutamine action. J. Cell Physiol. 2005;204:392-401.
Not in our library10.1002/jcp.20339
356.
New aspects of amino acid metabolism in cancer · 2019
No notice
357.
Xiao YR, et al. The m(6)A RNA demethylase FTO is a HIF-independent synthetic lethal partner with the VHL tumor suppressor. Proc. Natl Acad. Sci. USA. 2020;117:21441-21449.
Not in our library10.1073/pnas.2000516117
358.
Han ST, et al. Targeting ATF4-dependent pro-survival autophagy to synergize glutaminolysis inhibition. Theranostics. 2021;11:8464-8479.
Not in our library10.7150/thno.60028
359.
Zhou J, et al. N(6)-methyladenosine guides mRNA alternative translation during integrated stress response. Mol. Cell. 2018;69:636-647.e637.
Not in our library10.1016/j.molcel.2018.01.019
360.
Chen P, et al. Targeting YTHDF1 effectively re-sensitizes cisplatin-resistant colon cancer cells by modulating GLS-mediated glutamine metabolism. Mol. Ther.Oncol. 2021;20:228-239.
Not in our library10.1016/j.omto.2021.01.001
361.
Weng HY, et al. The m(6)A reader IGF2BP2 regulates glutamine metabolism and represents a therapeutic target in acute myeloid leukemia. Cancer Cell. 2022;40:1566.
Not in our library10.1016/j.ccell.2022.10.004
362.
Chen T, et al. WZ35 inhibits gastric cancer cell metastasis by depleting glutathione to promote cellular metabolic remodeling. Cancer Lett. 2023;555:216044.
Not in our library10.1016/j.canlet.2022.216044
363.
Han L, et al. METTL16 drives leukemogenesis and leukemia stem cell self-renewal by reprogramming BCAA metabolism. Cell Stem Cell. 2023;30:52.
Not in our library10.1016/j.stem.2022.12.006
364.
Immunometabolism at the Nexus of Cancer Therapeutic Efficacy and Resistance · 2021
Not checked
365.
Zhu YY, et al. The E3 ligase VHL promotes follicular helper T cell differentiation via glycolytic-epigenetic control. J. Exp. Med. 2019;216:1664-1681.
Not in our library10.1084/jem.20190337
366.
Chang CH, et al. Metabolic competition in the tumor microenvironment is a driver of cancer progression. Cell. 2015;162:1229-1241.
Not in our library10.1016/j.cell.2015.08.016
367.
Zhu X, Tang H, Yang M, Yin K. N6-methyladenosine in macrophage function: a novel target for metabolic diseases. Trends Endocrinol. Metab. 2023;34:66-84.
Not in our library10.1016/j.tem.2022.12.006
368.
Ning HF, et al. RBM4 regulates M1 macrophages polarization through targeting STAT1-mediated glycolysis. Int. Immunopharmacol. 2020;83:106432.
Not in our library10.1016/j.intimp.2020.106432
369.
Bian Y, et al. Cancer SLC43A2 alters T cell methionine metabolism and histone methylation. Nature. 2020;585:277-282.
Not in our library10.1038/s41586-020-2682-1
370.
Brand A, et al. LDHA-associated lactic acid production blunts tumor immunosurveillance by T and NK cells. Cell Metab. 2016;24:657-671.
Not in our library10.1016/j.cmet.2016.08.011
371.
Reinfeld BI, et al. Cell-programmed nutrient partitioning in the tumour microenvironment. Nature. 2021;593:282.
Not in our library10.1038/s41586-021-03442-1
372.
Gou YL, et al. Ectopic endometriotic stromal cells-derived lactate induces M2 macrophage polarization via Mettl3/Trib1/ERK/STAT3 signalling pathway in endometriosis. Immunology. 2023;168:389-402.
Not in our library10.1111/imm.13574
373.
Zhao W, et al. RNA helicase DDX5 participates in oxLDL-induced macrophage scavenger receptor 1 expression by suppressing mRNA degradation. Exp. Cell Res. 2018;366:114-120.
Not in our library10.1016/j.yexcr.2018.03.003
374.
PD-1 alters T-cell metabolic reprogramming by inhibiting glycolysis and promoting lipolysis and fatty acid oxidation · 2015
No notice
375.
Kumagai S, et al. An oncogenic alteration creates a microenvironment that promotes tumor progression by conferring a metabolic advantage to regulatory T cells. Immunity. 2020;53:187.
Not in our library10.1016/j.immuni.2020.06.016
376.
Cao W, et al. Oxidized lipids block antigen cross-presentation by dendritic cells in cancer. J. Immunol. 2014;192:2920-2931.
Not in our library10.4049/jimmunol.1302801
377.
Herber DL, et al. Lipid accumulation and dendritic cell dysfunction in cancer. Nat. Med. 2010;16:880-U857.
Not in our library10.1038/nm.2172
378.
Gokhale NS, Horner SM. RNA modifications go viral. Plos Pathog. 2017;13:e1006188.
Not in our library10.1371/journal.ppat.1006188
379.
Xue MG, et al. Viral RNA N6-methyladenosine modification modulates both innate and adaptive immune responses of human respiratory syncytial virus. PloS Pathog. 2021;17:e1010142.
Not in our library10.1371/journal.ppat.1010142
380.
Rubio RM, et al. RNA m(6) A modification enzymes shape innate responses to DNA by regulating interferon beta. Genes Dev. 2018;32:1472-1484.
Not in our library10.1101/gad.319475.118
381.
Xu J, et al. The RNA helicase DDX5 promotes viral infection via regulating N6-methyladenosine levels on the DHX58 and NFkappaB transcripts to dampen antiviral innate immunity. Plos Pathog. 2021;17:e1009530.
Not in our library10.1371/journal.ppat.1009530
382.
Liu Y, et al. N (6)-methyladenosine RNA modification-mediated cellular metabolism rewiring inhibits viral replication. Science. 2019;365:1171-1176.
Not in our library10.1126/science.aax4468
383.
Medzhitov R, Horng T. Transcriptional control of the inflammatory response. Nat. Rev. Immunol. 2009;9:692-703.
Not in our library10.1038/nri2634
384.
Hawiger J, Zienkiewicz J. Decoding inflammation, its causes, genomic responses, and emerging countermeasures. Scand. J. Immunol. 2019;90:e12812.
Not in our library10.1111/sji.12812
385.
METTL3 Attenuates LPS-Induced Inflammatory Response in Macrophages via NF- κ B Signaling Pathway · 2019
No notice
386.
Guo G, et al. Disease activity-associated alteration of mRNA m(5) C methylation in CD4(+) T cells of systemic lupus erythematosus. Front Cell Dev. Biol. 2020;8:430.
Not in our library10.3389/fcell.2020.00430
387.
Liu J, et al. CCR7 chemokine receptor-inducible lnc-Dpf3 restrains dendritic cell migration by inhibiting HIF-1alpha-mediated glycolysis. Immunity. 2019;50:600-615.e615.
Not in our library10.1016/j.immuni.2019.01.021
388.
Zheng LB, et al. RNA-m6A modification of HDGF mediated by Mettl3 aggravates the progression of atherosclerosis by regulating macrophages polarization via energy metabolism reprogramming. Biochem. Biophys. Res. Commun. 2022;635:120-127.
Not in our library10.1016/j.bbrc.2022.10.032
389.
Pan S, et al. N6-methyladenosine upregulates miR-181d-5p in exosomes derived from cancer-associated fibroblasts to inhibit 5-FU sensitivity by targeting NCALD in colorectal cancer. Int. J. Oncol. 2022;60:14.
Not in our library10.3892/ijo.2022.5304
390.
Sec62 promotes stemness and chemoresistance of human colorectal cancer through activating Wnt/β-catenin pathway · 2021
No notice
391.
Uddin MB, et al. An N(6)-methyladenosine at the transited codon 273 of p53 pre-mRNA promotes the expression of R273H mutant protein and drug resistance of cancer cells. Biochem Pharm. 2019;160:134-145.
Not in our library10.1016/j.bcp.2018.12.014
392.
Oncogene c-Myc promotes epitranscriptome m6A reader YTHDF1 expression in colorectal cancer · 2017
No notice
393.
Jiang Z, et al. Circular RNA protein tyrosine kinase 2 (circPTK2) promotes colorectal cancer proliferation, migration, invasion and chemoresistance. Bioengineered. 2022;13:810-823.
Not in our library10.1080/21655979.2021.2012952
394.
Ye X, et al. Increased m(6)A modification of lncRNA DBH-AS1 suppresses pancreatic cancer growth and gemcitabine resistance via the miR-3163/USP44 axis. Ann. Transl. Med. 2022;10:304.
Not in our library10.21037/atm-22-556
395.
Zhang C, et al. m(6)A methyltransferase METTL14-mediated upregulation of cytidine deaminase promoting gemcitabine resistance in pancreatic cancer. Front Oncol. 2021;11:696371.
Not in our library10.3389/fonc.2021.696371
396.
m6A demethylase ALKBH5 inhibits pancreatic cancer tumorigenesis by decreasing WIF-1 RNA methylation and mediating Wnt signaling · 2020
Retracted
397.
Wang L, et al. m(6) A RNA methyltransferases METTL3/14 regulate immune responses to anti-PD-1 therapy. EMBO J. 2020;39:e104514.
Not in our library10.15252/embj.2020104514
398.
Zheng H, et al. Decreased expression of programmed death ligand-L1 by seven in absentia homolog 2 in cholangiocarcinoma enhances T-cell-mediated antitumor activity. Front Immunol. 2022;13:845193.
Not in our library10.3389/fimmu.2022.845193
399.
Han D, et al. Anti-tumour immunity controlled through mRNA m(6)A methylation and YTHDF1 in dendritic cells. Nature. 2019;566:270-274.
Not in our library10.1038/s41586-019-0916-x
400.
m6A mRNA demethylase FTO regulates melanoma tumorigenicity and response to anti-PD-1 blockade · 2019
No notice
401.
Mimura K, et al. PD-L1 expression is mainly regulated by interferon gamma associated with JAK-STAT pathway in gastric cancer. Cancer Sci. 2018;109:43-53.
Not in our library10.1111/cas.13424
402.
Su R, et al. Targeting FTO suppresses cancer stem cell maintenance and immune evasion. Cancer Cell. 2020;38:79.
Not in our library10.1016/j.ccell.2020.04.017
403.
Yuan C, et al. Crosstalk of histone and RNA modifications identified a stromal-activated subtype with poor survival and resistance to immunotherapy in gastric cancer. Front. Pharm. 2022;13:868830.
Not in our library10.3389/fphar.2022.868830
404.
Li N, et al. ALKBH5 regulates anti-PD-1 therapy response by modulating lactate and suppressive immune cell accumulation in tumor microenvironment. Proc. Natl Acad. Sci. USA. 2020;117:20159-20170.
Not in our library10.1073/pnas.1918986117
405.
Zhu J, et al. Integrative analysis of m6A RNA methylation regulators and the tumor immune microenvironment in non-small-cell lung cancer. Dis. Mark. 2022;2022:2989200.
Not in our library10.1155/2022/2989200
406.
Ishizuka JJ, et al. Loss of ADAR1 in tumours overcomes resistance to immune checkpoint blockade. Nature. 2019;565:43.
Not in our library10.1038/s41586-018-0768-9
407.
Ma S, et al. The RNA m6A reader YTHDF2 controls NK cell antitumor and antiviral immunity. J. Exp. Med. 2021;218:e20210279.
Not in our library10.1084/jem.20210279
408.
METTL3-mediated m6A RNA methylation promotes the anti-tumour immunity of natural killer cells · 2021
No notice
409.
Chen B, et al. Development of cell-active N6-methyladenosine RNA demethylase FTO inhibitor. J. Am. Chem. Soc. 2012;134:17963-17971.
Not in our library10.1021/ja3064149
410.
Meclofenamic acid selectively inhibits FTO demethylation of m6A over ALKBH5 · 2014
No notice
411.
He W, et al. Identification of a novel small-molecule binding site of the fat mass and obesity associated protein (FTO). J. Med. Chem. 2015;58:7341-7348.
Not in our library10.1021/acs.jmedchem.5b00702
412.
Su R, et al. R-2HG exhibits anti-tumor activity by targeting FTO/m(6)A/MYC/CEBPA signaling. Cell. 2018;172:90-105.e123.
Not in our library10.1016/j.cell.2017.11.031
413.
Huang Y, et al. Small-molecule targeting of oncogenic FTO demethylase in acute myeloid leukemia. Cancer Cell. 2019;35:677-691.e610.
Not in our library10.1016/j.ccell.2019.03.006
414.
Xie GY, et al. A novel inhibitor of N-6-methyladenosine demethylase FTO induces mRNA methylation and shows anti-cancer activities. Acta Pharm. Sin. B. 2022;12:853-866.
Not in our library10.1016/j.apsb.2021.08.028
415.
Huff S, et al. Rational design and optimization of m(6)A-RNA demethylase FTO inhibitors as anticancer agents. J. Med. Chem. 2022;65:10920-10937.
Not in our library10.1021/acs.jmedchem.1c02075
416.
Qin B, et al. Discovery of novel mRNA demethylase FTO inhibitors against esophageal cancer. J. Enzym Inhib. Med. Chem. 2022;37:1995-2003.
Not in our library10.1080/14756366.2022.2098954
417.
Rational Design of Novel Anticancer Small-Molecule RNA m6A Demethylase ALKBH5 Inhibitors · 2021
Not checked
418.
Moroz-Omori EV, et al. METTL3 inhibitors for epitranscriptomic modulation of cellular processes. Chemmedchem. 2021;16:3035-3043.
Not in our library10.1002/cmdc.202100291
419.
Dolbois A, et al. 1,4,9-Triazaspiro[5.5]undecan-2-one derivatives as potent and selective METTL3 inhibitors. J. Med. Chem. 2021;64:12738-12760.
Not in our library10.1021/acs.jmedchem.1c00773
420.
Yankova E, et al. Small-molecule inhibition of METTL3 as a strategy against myeloid leukaemia. Nature. 2021;593:597.
Not in our library10.1038/s41586-021-03536-w
421.
N1-methyladenosine methylation in tRNA drives liver tumourigenesis by regulating cholesterol metabolism · 2021
No notice
422.
The Limitless Future of RNA Therapeutics · 2021
No notice
423.
Parr CJC, et al. N 1-Methylpseudouridine substitution enhances the performance of synthetic mRNA switches in cells. Nucleic Acids Res. 2020;48:e35.
Not in our library10.1093/nar/gkaa070
424.
Shatkin AJ. Capping of eucaryotic mRNAs. Cell. 1976;9:645-653.
Not in our library10.1016/0092-8674(76)90128-8
425.
Yan Y, et al. Non-viral vectors for RNA delivery. J. Control Release. 2022;342:241-279.
Not in our library10.1016/j.jconrel.2022.01.008
426.
Putney SD, Benkovic SJ, Schimmel PR. A DNA fragment with an alpha-phosphorothioate nucleotide at one end is asymmetrically blocked from digestion by exonuclease-iii and can be replicated invivo. Proc. Natl Acad. Sci. Biol. 1981;78:7350-7354.
Not in our library10.1073/pnas.78.12.7350
427.
Sasso JM, et al. The progress and promise of RNA medicine—an arsenal of targeted treatments. J. Med Chem. 2022;65:6975-7015.
Not in our library10.1021/acs.jmedchem.2c00024
428.
Springer AD, Dowdy SF. GalNAc-siRNA conjugates: leading the way for delivery of RNAi therapeutics. Nucleic Acid Ther. 2018;28:109-118.
Not in our library10.1089/nat.2018.0736
429.
Liu WW, Zhang ZY, Wang F, Wang H. Emerging roles of m6A RNA modification in cancer therapeutic resistance. Exp. Hematol. Oncol. 2023;12:21.
Not in our library10.1186/s40164-023-00386-2
430.
Taketo K, et al. The epitranscriptome m(6)A writer METTL3 promotes chemo- and radioresistance in pancreatic cancer cells. Int J. Oncol. 2018;52:621-629.
Not in our library10.3892/ijo.2017.4219
431.
Lai X, et al. Dysregulation of LINC00470 and METTL3 promotes chemoresistance and suppresses autophagy of chronic myelocytic leukaemia cells. J. Cell Mol. Med. 2021;25:4248-4259.
Not in our library10.1111/jcmm.16478
432.
Li X, et al. Fat mass and obesity-associated protein regulates tumorigenesis of arecoline-promoted human oral carcinoma. Cancer Med. 2021;10:6402-6415.
Not in our library10.1002/cam4.4188
433.
Wang X, et al. Fatty acid receptor GPR120 promotes breast cancer chemoresistance by upregulating ABC transporters expression and fatty acid synthesis. EBioMedicine. 2019;40:251-262.
Not in our library10.1016/j.ebiom.2018.12.037
434.
Wang LL, et al. m(6)A RNA methyltransferases METTL3/14 regulate immune responses to anti-PD-1 therapy. EMBO J. 2020;39:e104514.
Not in our library10.15252/embj.2020104514
435.
Chen H, et al. METTL3 inhibits antitumor immunity by targeting m(6)A-BHLHE41-CXCL1/CXCR2 axis to promote colorectal cancer. Gastroenterology. 2022;163:891-907.
Not in our library10.1053/j.gastro.2022.06.024
436.
Tsuruta N, et al. RNA N6-methyladenosine demethylase FTO regulates PD-L1 expression in colon cancer cells. Biochem. Biophys. Res. Commun. 2020;530:235-239.
Not in our library10.1016/j.bbrc.2020.06.153
437.
Wang Y, et al. Antibody-free enzyme-assisted chemical approach for detection of N6-methyladenosine. Nat. Chem. Biol. 2020;16:896.
Not in our library10.1038/s41589-020-0525-x
438.
Molinie B, et al. m(6)A-LAIC-seq reveals the census and complexity of the m(6)A epitranscriptome. Nat. Methods. 2016;13:692.
Not in our library10.1038/nmeth.3898
439.
Zhang Z, et al. Systematic calibration of epitranscriptomic maps using a synthetic modification-free RNA library. Nat. Methods. 2021;18:1213.
Not in our library10.1038/s41592-021-01280-7
440.
Tegowski M, Flamand MN, Meyer KD. scDART-seq reveals distinct m6A signatures and mRNA methylation heterogeneity in single cells. Mol. Cell. 2022;82:868.
Not in our library10.1016/j.molcel.2021.12.038
441.
Xu JN, et al. Abnormal oxidative metabolism in a quiet genomic background underlies clear cell papillary renal cell carcinoma. Elife. 2019;8:e38986.
Not in our library10.7554/elife.38986
442.
Dominissini D, et al. Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq. Nature. 2012;485:201-206.
Not in our library10.1038/nature11112
443.
Linder B, et al. Single-nucleotide-resolution mapping of m6A and m6Am throughout the transcriptome. Nat. Methods. 2015;12:767-772.
Not in our library10.1038/nmeth.3453
444.
Chen K, et al. High-resolution N(6) -methyladenosine (m(6) A) map using photo-crosslinking-assisted m(6) A sequencing. Angew. Chem. Int. Ed. Engl. 2015;54:1587-1590.
Not in our library10.1002/anie.201410647
445.
Zhang Z, et al. Single-base mapping of m(6)A by an antibody-independent method. Sci. Adv. 2019;5:eaax0250.
Not in our library10.1126/sciadv.aax0250
446.
Meyer KD. DART-seq: an antibody-free method for global m(6)A detection. Nat. Methods. 2019;16:1275-1280.
Not in our library10.1038/s41592-019-0570-0
447.
Atlas of quantitative single-base-resolution N6-methyl-adenine methylomes · 2019
No notice
448.
Wang Y, et al. Antibody-free enzyme-assisted chemical approach for detection of N(6)-methyladenosine. Nat. Chem. Biol. 2020;16:896-903.
Not in our library10.1038/s41589-020-0525-x
449.
Shu X, et al. A metabolic labeling method detects m(6)A transcriptome-wide at single base resolution. Nat. Chem. Biol. 2020;16:887-895.
Not in our library10.1038/s41589-020-0526-9
450.
Li X, et al. Transcriptome-wide mapping reveals reversible and dynamic N(1)-methyladenosine methylome. Nat. Chem. Biol. 2016;12:311-316.
Not in our library10.1038/nchembio.2040
451.
Li X, et al. Base-resolution mapping reveals distinct m(1)A methylome in nuclear- and mitochondrial-encoded transcripts. Mol. Cell. 2017;68:993-1005 e1009.
Not in our library10.1016/j.molcel.2017.10.019
452.
Khoddami V, Cairns BR. Identification of direct targets and modified bases of RNA cytosine methyltransferases. Nat. Biotechnol. 2013;31:458-464.
Not in our library10.1038/nbt.2566
453.
David R, et al. Transcriptome-Wide Mapping of RNA 5-Methylcytosine in Arabidopsis mRNAs and Noncoding RNAs. Plant Cell. 2017;29:445-460.
Not in our library10.1105/tpc.16.00751
454.
Cui X, et al. 5-methylcytosine RNA methylation in arabidopsis thaliana. Mol. Plant. 2017;10:1387-1399.
Not in our library10.1016/j.molp.2017.09.013
455.
Schwartz S, et al. Transcriptome-wide mapping reveals widespread dynamic-regulated pseudouridylation of ncRNA and mRNA. Cell. 2014;159:148-162.
Not in our library10.1016/j.cell.2014.08.028
456.
Li X, et al. Chemical pulldown reveals dynamic pseudouridylation of the mammalian transcriptome. Nat. Chem. Biol. 2015;11:592-597.
Not in our library10.1038/nchembio.1836
457.
Detection of internal N7-methylguanosine (m7G) RNA modifications by mutational profiling sequencing · 2019
No notice
458.
Malbec L, et al. Dynamic methylome of internal mRNA N(7)-methylguanosine and its regulatory role in translation. Cell Res. 2019;29:927-941.
Not in our library10.1038/s41422-019-0230-z
459.
Thalalla Gamage S, Sas-Chen A, Schwartz S, Meier JL. Quantitative nucleotide resolution profiling of RNA cytidine acetylation by ac4C-seq. Nat. Protoc. 2021;16:2286-2307.
Not in our library10.1038/s41596-021-00501-9
460.
Sakurai M, Suzuki T. Biochemical identification of A-to-I RNA editing sites by the inosine chemical erasing (ICE) method. Methods Mol. Biol. 2011;718:89-99.
Not in our library10.1007/978-1-61779-018-8_5

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