The role of furin cleavage site in SARS-CoV-2 spike protein-mediated membrane fusion in the presence or absence of trypsin

Abstract

The rapid spread of SARS-CoV-2 (also known as 2019-nCoV and HCoV-19 1 ), a novel lineage B betacoronavirus (βCoV), has caused a global pandemic of coronavirus disease (COVID-19). It has been speculated that RRAR, a unique furin-like cleavage site (FCS) in the spike protein (S), which is absent in other lineage B βCoVs, such as SARS-CoV, is responsible for its high infectivity and transmissibility. 2

Cited by papers we hold 8

• Evolution of the SARS‐CoV‐2 omicron variants BA.1 to BA.5: Implications for immune escape and transmission · 2022
  No notice
• Cryo-EM structure of a SARS-CoV-2 omicron spike protein ectodomain · 2022
  Not checked
• Molecular mechanism of interaction between SARS-CoV-2 and host cells and interventional therapy · 2021
  No notice
• COVID-19 Mechanisms in the Human Body—What We Know So Far · 2021
  Not checked
• Anti-inflammatory potential of Quercetin in COVID-19 treatment · 2021
  No notice
• A genome-wide CRISPR screen identifies host factors that regulate SARS-CoV-2 entry · 2021
  No notice
• Furin cleavage of SARS-CoV-2 Spike promotes but is not essential for infection and cell-cell fusion · 2021
  No notice
• ACE2/ADAM17/TMPRSS2 Interplay May Be the Main Risk Factor for COVID-19 · 2020
  No notice

Reads

A person counts once a day per paper. We keep no cookie and no address: a reader is a hash that changes every day. Any month under five reads shows no number.