Innate scavenger receptor-A regulates adaptive T helper cell responses to pathogen infection
Zhipeng Xu, Lei Xu, Wei Li and 13 more
Nature Communications · 2017
doi:10.1038/ncomms16035 (opens in a new tab)
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Abstract
Scavenger receptors can function as pattern recognition receptors to sense infection. Here the authors show that, in response to worm and bacterial infection, scavenger receptor class A prevents nuclear localization of IRF5 and thereby drives M2 polarization and associated type 2 immune responses.
Abstract licence: CC BY-NC-ND
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