YAP determines the cell fate of injured mouse hepatocytes in vivo
Norio Miyamura, Shoji Hata, Tohru Itoh and 9 more
Nature Communications · 2017
doi:10.1038/ncomms16017 (opens in a new tab)
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Abstract
Senescent and injured cells affect tissue functions and can drive tumorigenesis. Thus, efficient elimination of these cells is pivotal for tissue integrity. Here Miyamuraet al. show that YAP acts as a cellular stress sensor and promotes the elimination of damaged cells to maintain tissue homeostasis.
Abstract licence: CC BY-NC-ND
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